Prevalence of Acute-on-сhronic liver failure: Single-Center Study at the Mongolia-Japan Hospital
- VernacularTitle:Элэгний архаг дутмагшлын суурин дээр үүссэн цочмог дутагдлын тархалт ба үр дүн (Монгол-Япон эмнэлгийн жишээ дээр)
- Author:
Tamir L
1
,
2
;
Naranpurev M
1
,
2
Author Information
1. Department of Critical Care and Anesthesia, School of Medicine, MNUMS
2. Intensive care unit, Mongolia-Japan Hospital, MNUMS
- Publication Type:Other Types
- Keywords:
Grade;
Organ Failure;
Mortality
- From:
Mongolian Journal of Health Sciences
2025;88(4):100-104
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Acute-on-chronic liver failure (ACLF) is a clinical syndrome seen in patients with decompensated cirrhosis,
marked by organ failure and high risk of mortality. In Mongolia, liver cirrhosis and chronic liver disease are among the
leading causes of death, with mortality rates four times higher than the global average. Despite this, full data on ACLF in
the country remains insufficient.
Aim :This study aims to determine the prevalence, etiology, and outcomes of ACLF in patients admitted with acute de
compensated liver cirrhosis.
Materials and Methods :This retrospective registry study analyzed all hospital admissions at the Mongolia-Japan Hos
pital from Jan 1, 2022, to Dec 31, 2024. Definitions from the European Association for the Study of the Liver (EASL) and
the Chronic Liver Failure Consortium (EASL-CLIF) were used. Organ failure was assessed using the adapted Chronic
Liver Failure-Organ Failure (CLIF-OF) score. Patients with malignancies meeting the Milan criteria were excluded.
Results : A total of 83 patients were included, of whom 41% (n=34) met the ACLF criteria. Among ACLF patients, 58.8%
were male, with a median age of 52 years. The most common underlying cause of cirrhosis was viral hepatitis B and D.
The main triggers for ACLF were infection (50%) and alcoholic hepatitis (20.6%). ACLF grades were as follows: 29.4%
for Grade 1, 29.4% for Grade 2, and 41.1% for Grade 3. The overall in-hospital mortality rate was 28.9%, but it was
significantly higher in the ACLF group (75%) compared to the non-ACLF group (25%). Mortality rates increased with
ACLF grade: 20% for Grade 1, 50% for Grade 2, and 78.6% for Grade 3 (p < 0.00001).
Conclusion :1. The prevalence of acute-on-chronic liver failure (ACLF) among patients with decompensated cirrhosis was 41%,
with a notably high in-hospital mortality rate of 52.9%.
2. Bacterial infections, rather than hepatic insults, were the leading precipitating factors for ACLF, accounting for 50%
of the cases.
- Full text:2025052019245272995100-104.pdf
