Impact of Individual Temperament on the Immune  Response After COVID-19 Vaccination

Burenjargal B; Dashpagam O; Shatar Sh; Khongorzul T; Ariunzaya B; Zolmunkh N; Gansukh Ch; Ulziisaikhan B; Chimidtseren S; Baasanjargal B; Enkh-Amar B; Nomin-Erdene Ts; Davaalkham D; Tsogtsaikhan S; Batbaatar G

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Impact of Individual Temperament on the Immune Response After COVID-19 Vaccination

VernacularTitle: КОВИД-19-ийн эсрэг вакцины дараах эсрэгбиеийн урвалыг хувь хүний зан төрхтэй уялдуулан судалсан дүн
Author: Burenjargal B ^{1
,

2} ; Dashpagam O ^{2
,

3} ; Shatar Sh ² ; Khongorzul T ¹ ; Ariunzaya B ¹ ; Zolmunkh N ¹ ; Gansukh Ch ¹ ; Ulziisaikhan B ¹ ; Chimidtseren S ¹ ; Baasanjargal B ⁴ ; Enkh-Amar B ¹ ; Nomin-Erdene Ts ¹ ; Davaalkham D ² ; Tsogtsaikhan S ¹ ; Batbaatar G ¹
Author Information

1. Department of Immunology, School of Biomedicine, MNUMS
2. Department of Epidemiology and Biostatistics, School of Public Health, MNUMS
3. National Center for Communicable Diseases of Mongolia
4. Department of Physiology, School of Biomedicine, MNUMS
Publication Type:Other Types
Keywords: Temperament; COVID-19 vaccine; Immune response; Antibody; Personality traits
From: Mongolian Journal of Health Sciences 2025;88(4):47-51
CountryMongolia
Language:Mongolian
Abstract: Background: The first confirmed case of COVID-19 in Mongolia was reported on November 11, 2020. In response, the government imposed a nationwide lockdown, which significantly impacted the population’s mental health. Heightened levels of stress, anxiety, loneliness, and depression during the pandemic altered individuals’ psychological stability and behavior. Personality traits—defined as relatively stable patterns of emotion, cognition, and behavior—play a key role in stress responses and emotional regulation under pressure. Emerging evidence suggests that these psychological factors may influence the immune system’s responsiveness, including vaccine-induced antibody production.
Aim:To evaluate the association between post-vaccination antibody responses and personality types following two doses of COVID-19 vaccines.
Materials and Methods:A total of 738 participants who received two doses of COVID-19 vaccines (AstraZeneca ChAdOx1, n=29; Pfizer-BioNTech, n=119; Sinopharm BBIBP, n=590) and had no prior SARS-CoV-2 infection were enrolled. Serum samples were collected 21–28 days after the second dose, and SARS-CoV-2 RBD (S) IgG antibodies were measured using ELISA (Proteintech Inc., USA). Personality types were assessed using a 56-item temperament questionnaire developed by A. Belov, categorizing individuals into classical temperament types (choleric, phlegmatic, sanguine, melancholic). Logistic regression and ROC analysis were used to examine associations between personality types and antibody response.
Results:The presence of an antibody response was significantly higher among individuals with a melancholic tempera ment, and significantly lower among those with a phlegmatic temperament. Furthermore, antibody titers were higher in participants with melancholic and sanguine temperaments and lower in those with a phlegmatic type.
Conclusions:1. During the early period following the second dose of COVID-19 vaccination, the antibody response was higher in individuals with a pure melancholic temperament, while it was lower in those with a phlegmatic temperament. 2. After the second dose of the Sinopharm BBIBP COVID-19 vaccine, antibody titers were higher in individuals with pure melancholic and sanguine temperaments, and lower in those with a phlegmatic temperament.
Full text:202505201816481303147-51.pdf