Technologycal study of preparing tablet formulations from hepaclin-4 prescription
- VernacularTitle:Хепаклин-4 жороос шахмал эмийн хэлбэр гарган авах технологийн судалгаа
- Author:
Otgontsetseg B
1
;
Khuslen M
1
;
Byambasuren G
1
;
Tserendolgor B
1
Author Information
1. Department of pharmaceutical administration and management, Mongolian Univercity of Pharmaceutical Sciences
- Publication Type:Other Types
- Keywords:
Hepaclin-4;
Granules;
Combined Extract
- From:
Mongolian Journal of Health Sciences
2025;88(4):38-41
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:As of 2024, digestive system diseases rank fourth among the causes of mortality in Mongolia. Among
these, hepatocellular carcinoma (liver cancer) accounted for 20,501 deaths, leading in total mortality rates. In Traditional
Mongolian Medicine, Scutellaria baicalensis Georgi is used to cool blood heat, clear internal heat, and regulate imbal
ances; Saussurea amara L. is used for its antibacterial, anti-infective, and anti-inflammatory properties; Carthamus tinc
torius L. serves for disinfection, pain relief, fever reduction, and detoxification; and Chiazospermum erectum L. is used to
eliminate toxic heat and febrile conditions. Studies have confirmed that the Hepaclin-4 formulation exhibits antioxidant,
membrane-stabilizing, hepatoprotective, anti-necrotic, detoxifying activities, and reduces the accumulation of harmful
byproducts from excessive peroxidation. Therefore, developing a solid dosage form from the raw herbal materials of
Scutellaria baicalensis Georgi, Saussurea amara L., Carthamus tinctorius L., and Chiazospermum erectum L.in the He
paclin-4 formula forms the basis of our research.
Aim:To formulate and develop a tablet dosage form based on the compound prescription of Hepaclin-4
Materials and Methods: The raw materials of Scutellaria baicalensis Georgi, Saussurea amara L., Carthamus tinctorius
L., and Chiazospermum erectum L.were weighed at a 1:1:1:1 ratio and extracted with 40% ethanol at a 1:10 ratio using
the remaceration method. Ethanol was evaporated using a vacuum evaporator to obtain a thick extract, and quality indi
cators were determined. From the obtained thick extract, granules were prepared using two types of excipients through
the wet granulation method, and their quality characteristics were studied. Based on the most suitable granules, tablet
and capsule dosage forms were prepared and standardized according to the methods outlined in the Mongolian National
Pharmacopoeia.
Results:The Hepaclin-4 tablets were found to be round, well-formed, smooth, with intact edges, a slight characteristic
odor, no unpleasant taste, and light yellow in color. The friability resistance of the 0.5 g tablet was 99.6±0.08%, hardness
was 1.07±0.12 MPa, weight variation ranged from -2.6% to +3.9%, all within the acceptable 5% limit. The disintegration
time was 4.23±0.05 minutes, and dissolution was 95.4±0.47%, meeting the permissible standards. When flavonoids in the
tablets were detected by Thin Layer Chromatography (TLC), brownish-yellow spots appeared at Rf values identical to
standard quercetin (Rf=0.94) and rutin (Rf=0.48). The total flavonoid content, determined by Spectrophotometric Method
(SPM), was 0.165±0.01%.
Conclusion:Tablets were successfully developed from the thick extract of the Hepaclin-4 herbal compound. Upon eval
uation, the tablets met all the required technical specifications.
- Full text:202505201803020616538-41.pdf
