Comparison of umbilical cord blood gas parameters of newborns with the use of some labory induction drugs
- VernacularTitle:Төрөлт сэдээх зарим эмийн хэрэглээнд нярайн хүйн цусны хийн үзүүлэлтийг харьцуулсан дүн
- Author:
Oigonchimeg B
1
;
Sarnai S
1
;
Maralmaa T
1
;
Ser-Od B
1
;
Tsetsegsuren E
2
;
Gerelmaa B
3
;
Narantungalag D
1
Author Information
1. Department of Pharmacology, School of Bioscience, MNUMS
2. Department of Cardiovascular, The Third State Central Hospital
3. Department of Endocrinology, The Third State Central Hospital
- Publication Type:Journal Article
- Keywords:
labor induction;
labor augmentation;
cord blood gas;
lactat
- From:
Diagnosis
2024;110(3):40-46
- CountryMongolia
- Language:Mongolian
-
Abstract:
Background:Induction of labor is a procedure performed to prevent maternal and perinatal morbidity and mortality. The effects of birth control pills on babies are still controversial. Therefore, we conducted this study to compare the effects of oxytocin and misoprostol on fetal blood gas parameters.
Aim:To compare the effects of misoprostol and oxytocin used in labor induction on umbilical cord blood parameters
Materials and methods:We conducted this study among mothers who gave birth in the NICU, according to the inclusion criteria, a control group (n=30), misoprostol alone vaginally (n=30) and oxytocin drip alone (n= 30) and oxytocin with misoprostol group (n=30) 4 groups used 100 mothers were selected respectively. Umbilical artery blood was sampled and umbilical artery blood pH, pCO2, pO2, HCO3, and VE (blood base excess) parameters were measured in the laboratory. The umbilical cord blood acid-alkaline parameters and lactate levels were analyzed and evaluated using COBAS C311 and COBAS B221 instruments. It was compared and determined using SPSS26 and EXCEL programs.
Results:The average age of all mothers included in the study was 27.87±6.12, the average gestation period was 39.6±0.7 weeks, and the average weight of the newborn was 3466±323 gr. The average umbilical cord blood pH value was 7.34±0.04 in the control group, 7.25±0.07 in the oxytocin group, 7.27±0.04 in the misoprostol group, and 7.24±0.04 in the oxytocin and misoprostol group. And lactate valie was 5.8 in the control group, 7.5 in the oxytocin group, 9.87 in the misoprostol group, 8.7 in the combined group.
Conclusions:Compared to the group that did not use labor-inducing drugs, the mean pH of umbilical cord blood and lactate level were higher or statistically significant in the 3 groups that used labor-inducing drugs, indicating that birth-inducing drugs affect the umbilical cord blood parameters.
- Full text:2025052013472252425Diagnosis-2024-110(3)-40-46.pdf
