Title: Effect of Cacalia hastate.L 60 mg/kg for 7 and 14 days in treatment on model of Gastric ulcer
- VernacularTitle:Ходоодны шархлааны эмгэг загварт илдэн игүүшиний (Cacalia hastate L.) 60 мкг жингээр 7, 14 хоногуудад хэрэглэхэд үзүүлсэн нөлөөг судалсан үр дүнгээс
- Author:
Khulan B
1
;
Ariunaa S
1
;
Javzandulam E
1
;
Chimegsaikhan S
1
;
Jargalsaikhan B
2
;
Mandakhaa B
1
;
Tumenbayar B
1
;
Oyungerel S
1
;
Altantsetseg B
1
Author Information
1. Department of Histology, School of Bio Medicine, MNUMS
2. Urguu Maternity
- Publication Type:Journal Article
- From:
Diagnosis
2024;110(3):14-18
- CountryMongolia
- Language:Mongolian
-
Abstract:
Introduction Gastric ulcer is one of the most common disorders considering the gastrointestinal tract, it affects 5% of the population around the world, so its prevention and management are considered very important challenges. Researchers have revealed several causes
of gastric ulcer; these include an imbalance between aggressive and intrinsic defensive
factors. Gastric ulcer is a very common gastrointestinal disease that may lead to
dangerous complications and even death.
The aggressive factors include non-steroidal anti- inflammatory drugs(NSAID),alcohol,
psychological stress and Helicobacter pylori infection, cytoprotective intrinsic factors
include mucosal blood flow, bicarbonate, mucus, cell renewal, growth factors, NO
and prostaglandins, NSAID-induced gastric damage is known to be the most common
and dangerous side-effect of these drugs and accounts for 25% of gastric ulcer cases.
Indomethacin (INDO) is considered to be the most common NSAID known to induce experimental gastric ulcer and has been documented to have a higher potential to cause gastric injury than other commonly used NSAIDs.
Most of the drugs which are used for wound healing are imported in Mongolia. It is required to develop drug formulation and increase local productions used for the treatment of wound healing. For the
purpose of solving the above problems, we aimed to prepare new drug formulation from Cacalia hastata L. for the treatment.
of wound healing. Cacalia hastata L. is
a medicinal plant, member of the family
Asteraceae. Cacalia hastata L. is widely
used for the Mongolian traditional medicine
to
treat wound healing, gastric ulcer,
poisoning fever, liver fever, bile fever, oral
cavity, and gynecological diseases
- Full text:2025052013152687617Diagnosis-2024-110(3)-14-18.pdf
