Is Stem Cell-Based Therapy Going on or Out for Cardiac Disease?.

Author: Ki Hyun BYUN ¹ ; Sung Whan KIM
Author Information

1. Division of Cardiology, Department of Internal Medicine, Kwandong University College of Medicine, Goyang, Korea. cardio101@daum.net
Publication Type:Review ; Clinical Trial
Keywords: Stem cells; Cell differentiation; Cardiomyocytes; Regeneration
MeSH: Adult Stem Cells; Bone Marrow; Cause of Death; Cell Differentiation; Heart; Heart Failure; Humans; Induced Pluripotent Stem Cells; Myocardial Infarction; Myocytes, Cardiac; Perfusion; Regeneration; Stem Cells
From:Korean Circulation Journal 2009;39(3):87-92
CountryRepublic of Korea
Language:English
Abstract: Acute myocardial infarction and subsequent heart failure are leading causes of death worldwide. Stem cell-based therapies have improved cardiac function in recent clinical trials, but cardiomyocyte regeneration has not been demonstrated in human hearts. Angiogenesis and restoration of cardiac perfusion have been successfully performed using bone marrow derived stem cells and other adult stem cells. Resident cardiac stem cells are known to differentiate into multiple heart cell types, including cardiomyocytes. Furthermore, induced pluripotent stem cells are a focus of research due to the great potential for customized stem cell therapy.