Current status and prospects of phage therapy in lung transplantation
10.12464/j.issn.1674-7445.2025037
- VernacularTitle:噬菌体疗法在肺移植中的应用现状及展望
- Author:
Zhenyu ZHANG
1
;
Zitao WANG
1
;
Wenjie HUA
1
;
Zhenhang DAI
1
;
Jingyu CHEN
2
,
3
Author Information
1. Wuxi People's Hospital Affiliated to Nanjing Medical University, Lung Transplant Center of Jiangsu Province, Organ Transplantation Institute of Wuxi, Wuxi 214000, China.
2. Wuxi People's Hospital Affiliated to Nanjing Medical University, Lung Transplant Center of Jiangsu Province, Organ Transplantation Institute of Wuxi, Wuxi 214000, China
3. .
- Publication Type:ReviewArticle
- Keywords:
Phage therapy;
Lung transplantation;
Multidrug resistant organism;
Cystic fibrosis;
Antibiotics;
Bacteria;
Respiratory tract microbiota;
Pneumonia
- From:
Organ Transplantation
2025;16(3):489-494
- CountryChina
- Language:Chinese
-
Abstract:
Multidrug resistant organism refers to bacteria that are insensitive to three or more antibiotics commonly used in clinic, including Pseudomonas aeruginosa, Acinetobacter Baumannii and Klebsiella pneumoniae, etc. MDRO infection is a major factor affecting the survival rate after lung transplantation (LTx), accounting for 30% of the causes of death in the first year after transplantation. Antibiotic treatment has low specificity and is prone to drug resistance. The development of new drugs has a long cycle and high cost, with significant limitations. Phage has high specificity for bacteria, which can proliferate in large quantities in the infected lesion and co-evolve with bacteria during the action process. Phage also have a good killing effect on MDRO, which is expected to make up for the deficiencies of existing antibiotic therapy. This article reviews the development background and mechanism of action of phage therapy, and summarizes its application status and early clinical trial results in the field of LTx, in order to providing new thinking paths for clinical work.
