Result of studies on the toxicology and round healing activity of Gentiana Macrophylla Pall
- VernacularTitle:Том навчит дэгд (Gentiana Macrophylla Pall.) – ийн хорон чанар болон шархны эдгэрэлтэд нөлөөлөх идэвхийг судалсан дүн
- Author:
Delgermurun D
1
;
Sosorburam B
1
Author Information
1. Mongolian University of Life Sciences
- Publication Type:Journal Article
- Keywords:
total dry extract;
ointment and wound
- From:
Mongolian Pharmacy and Pharmacology
2024;24(1):33-38
- CountryMongolia
- Language:Mongolian
-
Abstract:
Gentiana macrophylla pall is used in Mongolian and Tibetan hospitals for various diseases such as flu, nephritis, enuresis, stroke, jaundice, rheumatism, pain relief, various wounds, fever due to inflammation, feverish inflammation of the stomach and intestines, chronic inflammation of the stomach, jaundice, and infectious diseases that is indicated in the textbooks. The Gentiana macrophylla is a medicinal plant that has been studied to some extent within the family of Gentianaceae, but there are many interesting and unexplored issues.
Therefore, in this study, we aimed to investigate skin wound healing activity in experimental rats and determine the median lethal dose (LD50 ) of Gentiana macrophylla pall. The total extract of Gentiana macrophylla pall was extracted by partial maceration with 80% ethanol, thickened and dried, median lethal dose (LD50 ) was determined by the method of V.B. Prozorovski and skin wound healing activity were determined by the method developed by (Mahboobeh Mehrabani Natanzi, 2012).
According to the results of the study, the toxicity of the total dry extract of Gentiana macrophylla was determined to be LD50 =0.397g/kg (0.329g/kg-0.477g/kg), and it was determined that this medicinal plant belongs to the category of less toxic plants. It was found that ointment prepared from the total dry extract of Gentiana macrophylla accelerates the regeneration of intentionally caused wounds in rats and accelerates wound healing.
Based on the results of this research, it has been scientifically established that Gentiana macrophylla supports the regeneration of open wounds and has an important therapeutic value to accelerate healing. In the future, it is necessary to study the mechanism of action of the ointment prepared from the total dry extract of Gentiana macrophylla applied to support wound healing and the activity of other treatments.
- Full text:2025051415390534460MPPJ-2024-24(1)-33-38.pdf
