Coronary Artery Thrombosis Associated With Paclitaxel in Advanced Ovarian Cancer.
10.4070/kcj.2009.39.3.124
- Author:
Sang Ho PARK
1
;
Jin Soo BYON
;
Se Whan LEE
;
Seung Jin LEE
;
Dong Kyu JIN
;
Won Yong SHIN
Author Information
1. Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, Cheonan, Korea. shinwy@schch.co.kr
- Publication Type:Case Report
- Keywords:
Paclitaxel;
Coronary thrombosis
- MeSH:
Arteries;
Aspirin;
Carcinoma;
Coronary Angiography;
Coronary Thrombosis;
Coronary Vessels;
Emergencies;
Female;
Follow-Up Studies;
Humans;
Middle Aged;
Myocardial Infarction;
Ovarian Neoplasms;
Paclitaxel;
Phenobarbital;
Thrombophilia;
Thrombosis;
Ticlopidine;
Tyrosine;
Ultrasonography, Interventional
- From:Korean Circulation Journal
2009;39(3):124-127
- CountryRepublic of Korea
- Language:English
-
Abstract:
A 63-year-old woman was diagnosed with ovarian cancer and peritoneal carcinomatosis. The day after paclitaxel was administered, an acute myocardial infarction occurred. Emergency coronary angiography revealed a filling defect in the left main coronary artery and total occlusion in the distal left anterior descending coronary artery, with no luminal irregularity or narrowing. Intravascular ultrasonography showed no significant plaque in the left main coronary artery. A thrombophilia work-up was negative, and the patient was treated with tirofiban, clopidogrel, and aspirin. The follow-up coronary angiogram showed that the occlusion of the distal obtuse marginal branch and distal left anterior descending artery had cleared. Paclitaxel has been associated with acute myocardial infarction. However, the pathogenesis of myocardial infarction associated with paclitaxel is not known. This case raises the possibility that paclitaxel can induce coronary artery thrombosis, resulting in myocardial infarction.
