Comparative immunohistochemical characterization of canine seminomas and Sertoli cell tumors.
- Author:
Chi Ho YU
1
;
Du Na HWANG
;
Ji Young YHEE
;
Jong Hyuk KIM
;
Keum Soon IM
;
Whan Gook NHO
;
Young Soo LYOO
;
Jung Hyang SUR
Author Information
- Publication Type:Original Article ; Comparative Study ; Research Support, Non-U.S. Gov't
- Keywords: dog; immunohistochemistry; seminoma; Sertoli cell tumor; tumor markers
- MeSH: Animals; Dog Diseases/*pathology; Dogs; Immunohistochemistry/*veterinary; Male; Seminoma/metabolism/pathology/*veterinary; Sertoli Cell Tumor/metabolism/pathology/*veterinary; Tumor Markers, Biological/metabolism
- From:Journal of Veterinary Science 2009;10(1):1-7
- CountryRepublic of Korea
- Language:English
- Abstract: Primary testicular tumors are the most common causes of cancer in male dogs. Overall, the majority of canine patients should be cured by testicular surgery. However, tumor markers are not well-known in veterinary medicine. We sought to determine using immunohistochemistry whether the combined human testicular tumor markers (placental alkaline phosphatase, OCT3/4, CD30, alpha-fetoprotein, inhibin-alpha, vimentin, c-KIT, and desmin) are expressed in canine seminomas and Sertoli cell tumors (SCTs). We examined 35 canine testicular tumors, 20 seminomas and 15 SCTs. c-KIT was expressed markedly in canine seminomas. Both inhibin-alpha and vimentin were expressed significantly in canine SCTs. The results of this study demonstrate differences and similarities between tumor marker expression of testicular tumors in dogs and humans. All the main markers in current routine use are discussed as well as potential useful markers for benign and malignant tumors, and tumor progression.
