A brief review on rat models of myocardial infraction
- VernacularTitle:Туршилтын харханд зүрхний шигдээс үүсгэх аргачлал, судалгаанд нэвтрүүлэх нь
- Author:
Davaasambuu T
1
;
Oyunchimeg B
1
;
Enkhbold G
1
;
Badamtsetseg S
1
;
Lkhaasuren L
1
;
Khurelbaatar L
1
,
2
Author Information
1. Drug Research Institute
2. Monos Group
- Publication Type:Review
- Keywords:
Myocardial infarction;
in-vivo model;
rat
- From:
Mongolian Pharmacy and Pharmacology
2024;25(2):85-94
- CountryMongolia
- Language:Mongolian
-
Abstract:
Myocardial infarction (Ml) is necrosis and death of heart muscle secondary to ischemia and acute coronary artery thrombosis. Ml, commonly known as a heart attack, happens when the oxygen rich blood flow to a part of the heart muscle is blocked for a prolonged period, causing damage or death to the heart tissue. This blockage is most often caused by a buildup of fat, cholesterol, and other substances, which form a plaque in the coronary arteries. Furthermore, patients with cancer constitute a high-risk population for cardiovascular disease and as of the last 5 years, 50% of patients with cardiovascular disease have been diagnosed with cancer, according to World Health Organization. The provision of complete insight into Ml complications along with designing ajpreventive program against Ml seems necessary. The use of medications has been practiced over the years for the prevention of HF. However, some of these medications produce adverse effects and due to high cost are not easily available to every patient. Over the past decades, there has been a significant rise in the use of herbal supplements based on traditional medicine to prevent, avoid, and/or treat different conditions, including cardiovascular disease; this rise results from a natural source, efficiency
with few or no adverse effects and low cost. In vivo models of heart failure (HF) and myocardial infarction (Ml) are essential for understanding the pathophysiology of these conditions and for developing new treatments.
These models typically involve inducing heart failure or myocardial infarction in animals, such as rodents to study disease mechanisms and evaluate potential therapies.
In this review, we discuss the most common preclinical models of Ml currently employed in cardiovascular research. Among them, Ml induced heart failure is a method of ligation of the left anterior descending artery of coronary an experimental animal. Its physiological relevance, cost-effective, uncomplicated, and suitable
method for evaluating research results. The rat model of myocardial infarction offers numerous advantages that make it a valuable tool for cardiovascular research.
- Full text:2025051315581750434MPPJ-2024-25(2)-85-94.pdf
