Anti-Inflammatory effects of some medicinal plants in LPS stimulated RAW264.7 macrophages
- VernacularTitle:Эмийн зарим ургамлын үрэвслийн эсрэг үйлдлийг липополисахаридаар өдөөгдсөн RAW-264.7 макрофаг эс дээр судалсан дүн
- Author:
Oyunchimeg B
1
,
2
,
3
;
Khandmaa D
1
;
Lkhaasuren L
1
;
Khurelbaatar L
1
;
Kim Xae Won
2
,
3
Author Information
1. Drug Research Inistitute, Monos Group
2. Institute of Economic Engineering, Dankook University, Korea
3. School of Nanobiomedical Sciences, Dankook University, Korea
- Publication Type:Journal Article
- Keywords:
inflammation;
cytokines;
iNOS;
IL-1b;
IL-6
- From:
Mongolian Pharmacy and Pharmacology
2024;25(2):58-63
- CountryMongolia
- Language:Mongolian
-
Abstract:
Abstract : Introduction: Medicinal herbs have been used in traditional medicine to treat systemic inflammatory disease for
many years. For instance, Rhodiola rosea L. extracts are used to enhance behavioural stresses for improving
fatigue and depression. Saposhnikovia divaricata notified to support function of musculoskeletal tissue and
to enhance tissue regeneration by its anti-inflammatory effect. The aim of this study was to investigate
therapeutic potential of four different types of medicinal plants (Rhodiola rosea L, Rhodiola quadrifidia (Pall)
Fisch, Saposhnikova divaricate (Turcz) Schischk and Salsola laricofolia Turcz.ex Litv).
Materials and methods: Anti-inflammatory effects of each extracts were evaluated separately using
chemically induced inflammatory model (RAW 264.7 macrophages). iNOS, IL-1β, IL-6 relative expression
was determined real-time reverse transcription-PCR.
Results: No cytotoxicity was observed with a concentration of herbal extract. LPS treated macrophages were
released cytokines at higher level and it was downregulated when plant extracts were treated. Herbal extract
treatment suppressed the production of iNOS, IL-1b and IL-6 from Raw264.7 cells after LPS.
Conclusion: These results demonstrate that herbal extracts exerts anti-inflammatory effects, which results
decreasing production of iNOS and pro-inflammatory cytokines and allowed us to screen future therapeutic
possibility.
- Full text:2025051315323507184MPPJ-2024-25(2)-58-63.pdf
