Serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies
10.13303/j.cjbt.issn.1004-549x.2025.04.014
- VernacularTitle:Rh和Kidd抗体引起溶血性输血反应的血清学探究
- Author:
Qunjuan ZENG
1
;
Hecai YANG
2
;
Xi LI
1
;
Yulin QIAN
1
;
Xin JIAO
1
Author Information
1. Dazhou Central Hospital, Dazhou 635000, China
2. Henan Red Cross Blood Center, Zhengzhou 450000, China
- Publication Type:Journal Article
- Keywords:
allogeneic transfusion;
unexpected antibodies;
mixed field;
haemolytic transfusion reaction
- From:
Chinese Journal of Blood Transfusion
2025;38(4):551-556
- CountryChina
- Language:Chinese
-
Abstract:
[Objective] To retrospectively analyse the serological characteristics of hemolytic transfusion reactions caused by Rh and Kidd antibodies, and to provide reference for safe, timely, and effective blood transfusion. [Methods] Two cases of patients with RhCcEe and Kidd blood type who experienced allogeneic transfusion at Dazhou Central Hospital were selected. A series of immunohematological tests were performed, including ABO, RhDCcEe and Kidd blood typing, unexpected antibody screening and identification, crossmatching, direct antiglobulin test, acid elution test, and capillary centrifugation to separate the patient's own red blood cells from donated red blood cells. [Results] Unexpected antibody screening, antibody identification, and direct antiglobulin test were positive in both patients. Case 1 had anti-Jk
in the plasma, but no specific antibodies were found in the eluate. Case 2 had anti-c and E in the plasma, and anti-E was detected in the eluate. High-speed capillary centrifugation revealed corresponding antigen-positive erythrocytes at the distal end of the blood samples of both patients. [Conclusion] Case 1 received Kidd allogeneic red blood cells, and case 2 received RhCcEe allogeneic red blood cells, and both patients developed the corresponding unexpected antibodies, which led to the occurrence of immune haemolytic blood transfusion reaction.
