Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province, China: characteristics and screening strategies

Yingnan DANG; Rong TANG; Liqin HUANG; Hailin WU; Tingting CHEN; Shengju LI; Yanli SUN; Xin ZHENG; Yanxia LI; Xianlin YE; Jinfeng ZENG

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Analysis of abnormal ALT in blood donors in five Zang autonomous prefectures of Qinghai Province, China: characteristics and screening strategies

VernacularTitle:青海省藏族自治州献血者丙氨酸氨基转移酶异常原因分析及血液筛查策略的探讨
Author: Yingnan DANG ¹ ; ² ; Rong TANG ³ ; Liqin HUANG ⁴ ; Hailin WU ¹ ; Tingting CHEN ⁴ ; Shengju LI ¹ ; Yanli SUN ⁴ ; Xin ZHENG ⁴ ; Yanxia LI ¹ ; Xianlin YE ⁴ ; Jinfeng ZENG ⁴
Author Information

1. Qinghai Provincial Blood Center, Xining 810000, China
2. National Center for Clinical Laboratories, Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing Hospital/National Center of Gerontology, Beijing 100730, China
3. Kunming Blood Center, Kunming 650106, China
4. Shenzhen Blood Center, Shenzhen 518035, China
Publication Type:Journal Article
Keywords: plateau; multi-ethnic; alanine aminotransferase (ALT); blood resources; screening strategies
From: Chinese Journal of Blood Transfusion 2025;38(4):502-507
CountryChina
Language:Chinese
Abstract: [Objective] To investigate the factors associated with alanine aminotransferase (ALT) abnormalities in multi-ethnic blood donors across five Zang autonomous prefectures in the plateau regions of Qinghai Province, and to provide evidence for ensuring blood safety and formulating screening strategies. [Methods] A retrospective analysis was performed on the ALT abnormal test results of blood donors in the Zang autonomous prefectures of Qinghai from 2022 to 2024. The correlations between ALT levels and factors including gender, age, altitude, and infectious markers were investigated. [Results] The overall ALT unqualified rate among blood donors in this region was 9.01%. Significant differences in ALT levels were observed across genders and age groups (P<0.05). Variations in ALT abnormality rates were also noted among different plateau regions (P<0.05). Overall, ALT values exhibited an increasing trend with rising altitude. The average ALT unqualified rates were 11.19% in Zang donors, 7.96% in Han donors, and 4.79% in donors from other ethnic groups (P<0.05). No statistically significant association was observed between ALT abnormality and the presence of HBV/HCV infectious markers (P>0.05). [Conclusion] In the plateau areas of Qinghai, multi-ethnic blood donors have a relatively high ALT levels and ALT unqualified rates, showing distinct regional characteristics. ALT elevation in voluntary blood donors is related to non-pathological factors such as gender, age, and dietary habits, but not to infectious indicators.