Effects of some syrups on citric acid induced cough in rat
- VernacularTitle:Харханд лимоны хүчлээр үүсгэсэн хуурай ханиалгын үед зарим сироп эмийн нөлөөлөх идэвх
- Author:
Munkh-Erdene R
1
;
Davaasambuu V
1
;
Bat-Oyun U
1
;
Ahsholpan B
1
;
Badamtsetseg S
1
;
LKhaasuren R
1
;
Hurelbaatar L
2
Author Information
1. Drug Research Institute
2. Monos Group
- Publication Type:Journal Article
- Keywords:
Cough, Malva sylvestris L;
Plantago asiatica L;
Influenza;
Respiratory disease
- From:
Mongolian Pharmacy and Pharmacology
2023;23(2):20-25
- CountryMongolia
- Language:Mongolian
-
Abstract:
Abstract: In Mongolia, flu and flu-like diseases affect many people, and pneumonia is a public health concern. Therefore, we have an urgent need to research and develop a new medicinal syrup to replace imported products using raw materials grown in Mongolia and to compare it with similar products. There are imported cough syrup products on the pharmaceutical market of Mongolia, but there are domestic pharmaceutical products. Moreover, there is limited research data on cough relief. The main goal of the research team is to compare the experimentally obtained syrup containing Plantago asiatica L, Malva Sylvestris L. and syrup containing Plantago major L. Juice, honey that produced by Monos Pharm LLC whish the cough relieving drug Gerbion syrup.
Material and methods: The vivarium of the pharmacology laboratory, Drug research institute,
TPC7062Ti mark IVC system (Shanghai Pretty Industries Co.,Ltd, China) in a special environment
with one care and one feeding regimen (Lab Mice Diet, Constant Formula Balanced Nutrition,
Jiangsu Xietong Pharmaceutical Bio- Engineering Co., LTD, China, www.jsxtsw.com ) used 64
non-WISTAR white rats weighing 180-218 g. Experimental rats were smoked with an aerosol of
17% citric acid aqueous solution for 5 minutes. The statistical processing of the research results
was done using the One-Way ANOVA/Multiple comparisons data of the GraphPad Prism 8 program.
Results and conclusion: Expressing the number of coughs produced in the experimental rats as
a percentage (%), the control group showed 3.95% cough relief, and the experimental group-1 by
48.4%, experimental group-2 by 71.1%, comparison group by 74.6%, respectively has reduced.
Experimental group -2 and comparison group for dry cough caused by citric acid 17%, it affects
the cough receptors in the mucous membrane of the respiratory tract and relaxes the bronchial
muscles (A and C fiber).
- Full text:2025051023130226825MPPJ-2023-23(2)-20-25.pdf
