Analysis of IL-2R β gene promoter region polymorphism in Han males from a high radiation background area in Yangjiang City
10.20001/j.issn.2095-2619.20250207
- VernacularTitle:阳江高本底地区汉族男性人群IL-2R β基因启动子区多态性分析
- Author:
Ying TANG
1
;
Jing WANG
;
Liting YAN
;
Wenting ZHONG
;
Cuiju WEN
;
Shibiao SU
Author Information
1. The 2nd Affiliated Hospital of Chengdu Medical College, Nuclear Industry 416 Hospital, Chengdu, Sichuan 610000, China
- Publication Type:Journal Article
- Keywords:
High radiation background area;
Interleukin-2 receptor β chain;
Gene polymorphism;
Gene frequency;
Alleles;
Genotype;
Genetic variation
- From:
China Occupational Medicine
2025;52(1):45-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the distribution characteristics of the single nucleotide polymorphism (SNP) site rs76206423 in the promoter region of the interleukin-2 receptor (IL-2R) β gene among Han males in a high radiation background area (HBRA) in Yangjiang City. Methods A total of 48 male participants from Tangkou Town, Yangxi County, Yangjiang City (HBRA group), and 51 male participants from Hengpo Town, Enping City (control group) were selected as the research subjects using the random number table method. Peripheral venous blood samples of participants from both groups were collected, and genomic DNA was extracted. The genotyping and allele frequency distribution of the rs76206423 (A/G) site in the IL-2R β promoter region was detected among the participants in both groups using the SNP detection method. The difference of allele frequencies between population in HBRA group and five area of East Asia, South Asia, Africa, Europe, and the Americas published in the Human Genome Project database from National Center for Biotechnology Information were analyzed. Results The allele frequencies of rs76206423 of population in both groups conformed to Hardy-Weinberg equilibrium (P>0.05). In the HBRA group, the AA genotype was predominant (64.6%), while the AG genotype was the most common in the control group (51.0%), with a significant difference (P<0.05). Population in both groups showed a predominance of the variant allele A (78.1% and 72.5%, respectively), with no significant difference (P>0.05). The frequency of the G allele of rs76206423 in the population in HBRA group was higher than those in South Asian, African, European, and American populations (all P<0.01), but showed no significant difference compared with East Asian populations (P>0.05). Conclusion In the Han male population from the HBRA in Yangjiang City, the rs76206423 site in the IL-2R β gene promoter region is predominantly composed of the wild-type A allele and AA genotype, indicating genetic stability and a relatively high degree of variation at this locus.
