Research progress on the effects of low dose radiation on DNA damage repair
10.20001/j.issn.2095-2619.20241217
- VernacularTitle:低剂量电离辐射对DNA损伤修复影响研究进展
- Author:
Xiang LI
1
;
Ming LIU
;
Haihui LIN
;
Yinghong WEI
;
Shibiao SU
Author Information
1. Institute of Occupational Health Assessment, Guangdong Provincial Hospital for Occupational Disease Prevention and Treatment, Guangzhou, Guangdong 510300, China
- Publication Type:Review
- Keywords:
Low dose radiation;
DNA damage;
DNA repair;
DNA damage response;
DNA double strand break;
Biological effect;
Radiation protection;
Research progress
- From:
China Occupational Medicine
2024;51(6):700-706
- CountryChina
- Language:Chinese
-
Abstract:
Low dose radiation (LDR) is a relatively low dose, but it is important in the fields of occupational health, medical radiation protection and environmental protection. Therefore, the effects of LDR on DNA damage repair and its potential mechanisms have attracted increasing attention. LDR mainly acts on DNA molecules in direct or indirect ways, leading to DNA double strand breaks (DSBs), which then triggers DNA damage, forms cluster damage, and induces DNA damage repair, which has a potential impact on organisms. However, long-term LDR exposure may lead to dysfunction of the DNA repair system and increase the risk of accumulating DNA damage. LDR-induced DNA damage response is an adaptive response, with DNA damage repair being one of its main mechanisms. The repair of DSBs is particularly important, with the main repair methods including homologous recombination and non-homologous end joining. LDR may also trigger adaptive responses by activating immune cells, enhancing cellular antioxidant capacities, and through varies of specific biological mechanisms such as immune/inflammatory response and antioxidant responses. The biological effects of LDR mainly include cell stress response, cell cycle regulation and bystander effect. In the future, it is necessary to further explore the molecular mechanism of LDR's impact on organism health and evaluate its impact on radiation risk assessment and individualized protective measures, to better understand the basic principles of radiation biology and provide scientific basis for radiation protection, risk assessment and injury treatment.
