Paclitaxel Oral Preparations： A Review
10.13422/j.cnki.syfjx.20250762
- VernacularTitle:紫杉醇口服制剂的研究进展
- Author:
Jie GAO
1
;
Shiyang LI
1
;
Jing GUO
2
;
Rongsheng LI
3
;
Zhenyu XUAN
1
Author Information
1. School of Chinese Materia Medica，Shanghai University of Traditional Chinese Medicine， Shanghai 201203，China
2. Suzhou Youseen New Drug Research&Development Co. Ltd.，Suzhou 215125，China
3. Wuya College of Innovation，Shenyang Pharmaceutical University，Shenyang 110016，China
- Publication Type:Journal Article
- Keywords:
paclitaxel;
preparation;
oral administration;
drug delivery system;
anti-cancer;
bioavailability;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(11):322-330
- CountryChina
- Language:Chinese
-
Abstract:
Paclitaxel， a highly effective natural antitumor drug， has been demonstrated to be efficacious in the treatment of a variety of cancers， including breast cancer， ovarian cancer， and lung cancer. The traditional paclitaxel injections have been observed to present certain issues， including overt adverse reactions and a decline in the quality of life of patients following treatment. This ultimately leads to an inability to meet the comprehensive needs of patients， thereby limiting the clinical applications of the drugs. Compared with injectable administration， the oral administration can avoid the risk of infection present in the invasive route， is conducive to improving patient compliance and quality of life， and reduces healthcare costs， and has a good application prospect. However， paclitaxel has low solubility， poor permeability， and is susceptible to the exocytosis of P-glycoprotein， which presents a significant challenge in the development of its oral preparations. Novel drug delivery technologies can enhance the solubility of paclitaxel and facilitate its controlled release， which is beneficial for the oral absorption and efficacy. The paper reviews the development history of oral preparations of paclitaxel， and summarizes the delivery technologies such as polymer micelles， nanoparticles， nanoemulsions and nanocrystals， and discusses the application mechanisms， advantages and limitations of these technologies and their adaptability in different cancer treatments. Finally， the challenges faced in the development of oral preparations of paclitaxel are summarized， and future research directions are proposed in order to provide new ideas for the development of oral delivery of paclitaxel.
