Literature Based Analysis on Adverse Reactions in Simultaneously Clinical Use of Banxia （Rhizoma Pinelliae）- Wutou （Aconitum）
10.13288/j.11-2166/r.2025.09.014
- VernacularTitle:基于文献的半夏乌头类反药组合临床同方使用不良反应分析
- Author:
Can CAO
1
;
Wenyong LIAO
1
;
Jiwen ZHANG
1
;
Yinghao WU
1
;
Xiangnan XU
1
;
Meijing WU
1
;
Xiaoqing LIU
1
;
Shaohong CHEN
1
;
Haiyan LIU
1
;
Linlin XIU
1
;
Xiangqing CUI
1
;
Gaoyang LI
2
;
Ying ZHANG
1
;
Gansheng ZHONG
1
Author Information
1. School of Traditional Chinese Medicine，Beijing University of Chinese Medicine，Beijing，102488
2. Lingyan Innovation （Beijing） Health Technology Co.，Ltd.
- Publication Type:Journal Article
- Keywords:
eighteen antagonisms;
Banxia （Rhizoma Pinelliae）;
Wutou （Aconitum）;
adverse reactions;
antagonistic herb combinations
- From:
Journal of Traditional Chinese Medicine
2025;66(9):955-962
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo analyze the adverse reactions associated with the clinical use of Banxia （Rhizoma Pinelliae）- Wutou （Aconitum） in the same formula， with the aim of providing a reference for the safety of their clinical application. MethodsLiterature on the clinical application of antagonistic herbs "Banxia-Wutou" used in the same formula， published from January 1st， 2014， to June 30th， 2023， was retrieved from databases including CNKI， VIP， Wanfang， SinoMed， PubMed， Cochrane Library， and Embase. A database was established， and information related to adverse reactions was extracted， including descriptions， classifications， specific manifestations， management and outcomes， patients' primary diseases （western medicine diseases and traditional Chinese medicine diagnoses and syndromes）， and medication information （dosage， ratio， administration routes， and dosage forms）. ResultsA total of 79 researches simultaneously used antagonistic herbs Banxia-Wutou in the same formula and reported associated advers reactions. Gastrointestinal adverse reactions were the most common， with 8 studies reporting management of adverse reactions and 3 studies reporting improvement with no intervention. Among the 11 researches， the adverse reaction relieved to extant， while other 69 researches didn't report the managment of adverse reaction and its prognosis. For the primary disease in western medicine system， chronic bronchitis and chronic obstructive pulmonary disease （COPD） were most common， while gastric pain was the most common symptom in traditional Chinese medicine with spleen and kidney deficiency and spleen stomach cold deficiency being the most frequent syndromes. The most common Banxia dosage was 10 g， while for the Wutou， Fuzi （Radix Aconiti Lateralis Praeparata） was predominant with the highest dose at 15 g. The most frequent herbal combination was Banxia-fuzi， with a 1∶1 ratio. The main administration route was oral， and the primary dosage form was decoction. ConclusionGastrointestinal adverse reactions are the most common in the clinical use of Banxia-Wutou antagonistic herb combinations. Research on the safety of "Banxia-Wutou" combinations should focus on respiratory system diseases and spleen-stomach related conditions.
