Mechanism of Mitochondrial Autophagy and Intervention of Traditional Chinese Medicine in Renal Fibrosis： A Review
10.13422/j.cnki.syfjx.20250140
- VernacularTitle:线粒体自噬在肾纤维化中的作用机制及中医药干预研究进展
- Author:
Shuqi MIN
1
;
Chenghua ZHANG
2
;
Qiwang HE
3
;
Xinyue ZHANG
1
;
Zhiyi LI
1
;
Meifeng ZHU
2
;
Shenju WANG
2
Author Information
1. Nanjing University of Chinese Medicine， Nanjing 210023， China
2. Changzhou Hospital of Traditional Chinese Medicine， Nanjing University of Chinese Medicine， Changzhou 213000， China
3. College of Acupuncture and Orthopedics， Hubei University of Chinese Medicine， Wuhan 430061， China
- Publication Type:Journal Article
- Keywords:
mitochondrial autophagy;
renal fibrosis;
mechanism of action;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(11):314-321
- CountryChina
- Language:Chinese
-
Abstract:
With the main pathological features of glomerulosclerosis and interstitial fibrosis， renal fibrosis is a key pathological process causing chronic kidney disease to progress to end-stage disease. As a cellular autophagic process， mitochondrial autophagy plays a crucial role in maintaining mitochondrial mass and functional stability. Mitochondrial dysfunction is considered to be one of the key factors driving the progression of fibrosis. Phosphatase and tension protein homologue （PTEN） induce various signalling pathways such as putative kinase 1/parkin， Nip3-like protein X/Bcl-2 interacting protein 3， and FUN14 structural domain-containing protein 1 to activate mitochondrial autophagy to participate in the regulation of fibrogenic factors， amelioration of oxidative stress， and inhibition of inflammatory response and apoptosis， which in turn effectively slows down the progression of renal fibrosis. Studies have shown that traditional Chinese medicine monomers and compound preparations， including phenolics， terpenoids， ketones， and alkaloids， can regulate mitochondrial autophagy-related signalling pathways and achieve significant clinical efficacy in intervening in the progression of renal fibrosis for the treatment of chronic kidney disease. This paper summarized the mechanism of mitochondrial autophagy and the research progress of traditional Chinese medicine intervention in renal fibrosis to provide new ideas for the study of the mechanism of traditional Chinese medicine in treating renal fibrosis.
