Traditional Chinese Medicine Intervention in Diabetic Nephropathy Based on PI3K/Akt Signaling Pathway： A Review
10.13422/j.cnki.syfjx.20250727
- VernacularTitle:基于PI3K/Akt信号通路探讨中医药干预糖尿病肾病的研究进展
- Author:
Miao XU
1
;
Xiaolei JIA
2
;
Lingling QIN
1
;
Haiyan WANG
1
;
You WANG
1
;
Yuzhuo CHANG
1
;
Cuiyan LYU
3
;
Tonghua LIU
1
Author Information
1. Beijing University of Chinese Medicine， Beijing 100029， China
2. Beijing University of Chinese Medicine Third Affiliated Hospital， Beijing 100029， China
3. Beijing Hospital of Traditional Chinese Medicine， Capital Medical University， Beijing 100010， China
- Publication Type:Journal Article
- Keywords:
phosphatidylinositol 3-kinase /protein kinase B （PI3K/Akt） signaling pathway;
diabetes nephropathy（DN）;
mechanism of action;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(11):90-97
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy （DN） is a renal disorder induced by prolonged hyperglycemia， with major pathological features including persistent albuminuria， progressive decline in glomerular filtration rate， and elevated arterial blood pressure. As one of the most common and severe microvascular complications of diabetes， the pathogenesis of DN is complex and multifactorial. Without timely and effective treatment， DN may eventually progress to end-stage renal disease （ESRD）. Currently available therapeutic options are often associated with significant adverse effects and high costs， and a large number of patients still progress to ESRD due to delayed treatment. Therefore， there is an urgent need for safer and more effective treatment strategies to improve the living standards and enhance the survival and quality of life of patients with DN. Modern studies have demonstrated that the phosphatidylinositol 3-kinase （PI3K）/protein kinase B （Akt） signaling pathway plays a critical role in oxidative stress， inflammatory responses， autophagy， and glycolysis， and is closely associated with the pathophysiological progression of DN. In recent years， traditional Chinese medicine （TCM） has achieved remarkable progress in the prevention and treatment of DN， supported by rich clinical experience and confirmed therapeutic efficacy. With its characteristics of multi-target， multi-component， and multi-pathway actions， along with minimal side effects， TCM can delay the progression of DN and alleviate patient symptoms. Among these mechanisms， the regulation of the PI3K/Akt signaling pathway has gradually become a research hotspot. This paper systematically reviews the role and mechanisms of the PI3K/Akt signaling pathway in the onset and progression of DN based on extensive literature research， summarizes the latest research advances on the precise modulation of the PI3K/Akt pathway by Chinese medicine monomers， active constituents， Chinese patent medicines， and herbal compound formulas in the treatment of DN， aiming to provide a strong theoretical reference for the development of clinically effective agents for DN prevention and treatment.
