Comparison of nutritional intervention effects at different initiation time in patients with respiratory diseases at nutritional risk
10.12025/j.issn.1008-6358.2025.20241189
- VernacularTitle:存在营养风险呼吸系统疾病患者不同启动时间营养干预效果比较
- Author:
Lihong WANG
1
,
2
;
Yuan CUI
3
;
Shaoye HUO
3
;
Yunhua ZHAO
3
;
Yuhuan WEI
3
;
Rong JIANG
4
;
Chunhai SHAO
1
,
5
,
6
Author Information
1. Department of Clinical Nutrition, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China
2. Centre for Community Health Research, Fudan University, Shanghai 200240, China.
3. Department of Clinical Nutrition, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China.
4. Department of Respiratory Medicine, Shanghai Fifth People’s Hospital, Fudan University, Shanghai 200240, China.
5. Centre for Community Health Research, Fudan University, Shanghai 200240, China
6. Department of Clinical Nutrition, Huashan Hospital, Fudan University, Shanghai 200040, China.
- Publication Type:Originalarticle
- Keywords:
nutritional intervention;
initiation time;
respiratory disease;
inflammation response;
nutritional status
- From:
Chinese Journal of Clinical Medicine
2025;32(2):268-275
- CountryChina
- Language:Chinese
-
Abstract:
Objective To assess the effect of early nutritional intervention on the patients with respiratory diseases at nutritional risk. Methods A total of 130 patients with respiratory disease who were hospitalized in Shanghai Fifth People’s Hospital, Fudan University between May 2023 and December 2024 and had a nutritional risk screening 2002 score ≥3 points. Based on the initiation time of nutritional intervention, patients were divided into an early group (≤5 days, n＝65) and a late group (＞5 days, n＝65). Results In the early group, prealbumin (P-ALB) and retinol-binding protein (RBP) levels were significantly higher (P＜0.01), C-reactive protein (CRP), procalcitonin (PCT) levels were significantly lower after intervention (P＜0.05). Compared with the late group, the hospital costs were lower and hospital stays were shorter in the early group (P＜0.001). Spearman analysis showed ALB, P-ALB, and total protein (TP) were negatively correlated with hospital costs (r＝－0.37, －0.20, and－0.22, P＜0.05). RBP, ALB, P-ALB, and lymphocyte count (LYM) were negatively correlated with CRP (r＝－0.30, －0.26, －0.37, －0.18, P＜0.01), RBP, ALB, P-ALB, hemoglobin (HB), and TP were negatively correlated with PCT (r＝－0.23,－0.36, －0.40, －0.30, －0.19, P＜0.05). Conclusions For patients with respiratory diseases, early nutritional assessment should be underwent, and for patients with nutritional risk screening 2002 score ≥3 points, early nutritional intervention could improve the nutritional status and alleviate inflammatory response, promote recovery, shorten the hospital stays.
