A Case of Acute Anterior Uveitis Associated with HLA-B27 Positivity after Intravitreal Injection of Bevacizumab.
10.3341/jkos.2013.54.12.1945
- Author:
Jang Won SEO
1
;
Yoon Hyung KWON
Author Information
1. Department of Ophthalmology, Dong-A University College of Medicine, Busan, Korea. yhkwon@dau.ac.kr
- Publication Type:Case Report
- Keywords:
Acute anterior uveitis;
Bevacizumab;
HLA-B27 positive;
Hypopyon;
Intravitreal injection
- MeSH:
Adult;
Anterior Chamber;
Atropine;
Endophthalmitis;
Hemorrhage;
HLA-B27 Antigen*;
Humans;
Inflammation;
Intravitreal Injections*;
Male;
Prednisolone;
Retinal Vein;
Uveitis, Anterior*;
Visual Acuity;
Bevacizumab
- From:Journal of the Korean Ophthalmological Society
2013;54(12):1945-1949
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: Intravitreal injection of bevacizumab (Avastin(R)) can lead to several intraocular complications including endophthalmitis, hemorrhage and inflammation. We present one case of acute anterior uveitis with hypopyon in an HLA-B27(+) patient following intravitreal injection of bevacizumab. CASE SUMMARY: A 40-year-old male with known central retinal vein occlusion presented with redness and decreased visual acuity in the left eye. Symptoms had developed 4 days earlier after the sixth intravitreal injection of bevacizumab in that eye. The patient had a marked anterior chamber reaction with hypopyon and posterior synechiae. Nine days after onset, similar symptoms in the left eye occurred in the uninjected right eye. Through examination and clinical manifestations, we diagnosed acute anterior uveitis associated with HLA-B27 positivity. The patient was treated with 1% prednisolone acetate, 0.5% moxifloxacin and 1% atropine in both eyes and all symptoms had resolved after 6 weeks.
