Application of utricle function testing in different clinical stages of Meniere’s disease
10.12025/j.issn.1008-6358.2025.20250086
- VernacularTitle:椭圆囊功能检测在梅尼埃病不同临床分期中的应用
- Author:
Yuanling LI
1
;
Xiaofei LI
1
;
Yongdong SONG
1
;
Yafeng LÜ
1
;
Yueling CHEN
1
;
Daogong ZHANG
1
Author Information
1. Shandong University, Department of Vertigo, Shandong Provincial ENT Hospital, Jinan 250022, Shandong, China.
- Publication Type:Monographicreport:Multi-disciplinarydiagnosisandtreatmentofvertigo
- Keywords:
Meniere’s disease;
utricle;
clinical staging;
ocular vestibular evoked myogenic potential;
unilateral centrifugation subjective visual vertical
- From:
Chinese Journal of Clinical Medicine
2025;32(2):171-176
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the role of ocular vestibular evoked myogenic potential (oVEMP) and unilateral centrifugation subjective visual vertical (UC-SVV) tests in evaluating the utricular function of patients with Meniere’s disease (MD) at different clinical stages. Methods A total of 97 unilateral MD patients at Shandong Provincial ENT Hospital from July 2019 to September 2021 were selected. All patients underwent oVEMP, UC-SVV, and pure tone audiometry tests. MD patients were classified into clinical stages 1, 2, 3, and 4, with stages 1 and 2 defined as early stage and stages 3 and 4 as late stage. The results of utricular function tests (abnormal rates of oVEMP, UC-SVV, and oVEMP＋UC-SVV) were compared among patients at different stages. Spearman correlation analysis was used to evaluate the correlation between utricular function and clinical staging. Results Among the 97 MD patients, the abnormal rate of oVEMP was 66.0% (64/97), and the abnormal rate of UC-SVV was 55.7% (54/97). The abnormal rates of oVEMP and oVEMP＋UC-SVV in early-stage patients were significantly lower than those in late-stage patients (P＜0.05), while the difference in UC-SVV abnormal rates between the two groups was not statistically significant. Intra-group comparisons showed that the abnormal rate of oVEMP＋UC-SVV in stage 1 patients was significantly lower than that in stage 2 patients (P＜0.05), without significant difference in the other indices. There were no significant differences among the three indices in stages 3 and 4 patients. Spearman correlation test results indicated that the abnormal rate of oVEMP (r＝0.336, P＝0.001) and the abnormal rate of oVEMP＋UC-SVV (r＝0.301, P＝0.003) were weakly positively correlated with clinical staging, while there was no correlation between the abnormal rate of UC-SVV and clinical staging (r＝0.022, P＝0.832). Conclusions Both oVEMP and UC-SVV tests can assess utricular function in MD patients at different clinical stages. Their combination is helpful of early-stage (stages 1 and 2) MD diagnosis.
