The characteristics and mechanism of dynamic changes of different components in microenvironment in regulating the progression of liver fibrosis
- VernacularTitle:微环境不同组分动态变化调控肝纤维化发展的特征与机制
- Author:
Huilan ZHAO
1
;
Zongxu LIU
1
;
Shumin LI
1
;
Zhifeng WANG
1
;
Minghui LIU
1
;
Qian SHENG
1
;
Kunbin KE
2
;
Xinan SHI
1
Author Information
- Publication Type:Review
- Keywords: Cellular Microenvironment; Hepatic Fibrosis; Hepatic Stellate Cells; Kupffer Cells; Liver Sinusoidal Endothelial Cells
- From: Journal of Clinical Hepatology 2025;41(4):755-760
- CountryChina
- Language:Chinese
- Abstract: The liver has diverse functions such as metabolism， detoxification， and immune defense， and the maintenance of hepatic microenvironment homeostasis is crucial for overall bodily health. The hepatic microenvironment consists of the components such as parenchymal cells， non-parenchymal cells， and non-cellular components. Chronic inflammatory responses induced by various etiological factors may promote the formation and progression of liver fibrosis. During the dynamic progression of liver fibrosis， from the early to advanced stages， various components within the hepatic microenvironment undergo a series of changes， which can promote the malignant progression of liver fibrosis. An in-depth exploration of the mechanisms underlying such changes in each component of the liver fibrosis microenvironment is of great significance for understanding the pathogenesis of liver fibrosis and discovering potential treatment strategies.
