The mechanism and clinical application value of interleukin-10 family in anti-hepatic fibrosis
- VernacularTitle:白细胞介素-10家族抗肝纤维化的作用机制及临床应用价值
- Author:
Qi LUO
1
;
Biyu ZENG
1
;
Rong ZHANG
1
;
Liangjiang HUANG
2
;
Lei FU
3
;
Chun YAO
1
Author Information
- Publication Type:Review
- Keywords: Hepatic Fibrosis; Interleukin-10; Integrated Traditional Chinese Medicine & Western Medicine
- From: Journal of Clinical Hepatology 2025;41(4):748-754
- CountryChina
- Language:Chinese
- Abstract: The interleukin-10 （IL-10） family is expressed in various types of cells and has a wide range of biological functions， and it plays an important role in the development and progression of hepatic fibrosis. Hepatic fibrosis is a chronic liver disease characterized by abnormal repair of hepatic tissues after injury， activation of hepatic stellate cells， and excessive accumulation of extracellular matrix. The IL-10 family members include IL-10， IL-19， IL-20， IL-22， IL-24， IL-26， IL-28， IL-29， and IL-35， with similarities in structure and function， and changes in their expression levels are closely associated with the progression of hepatic fibrosis. Moderate upregulation of the expression of IL-10 family members can help maintain the quiescent state of hepatic stellate cells， promote the transformation of macrophages to anti-inflammatory phenotype， and regulate the activity of natural killer cells， thereby inhibiting inflammatory response， regulating cell apoptosis and autophagy， and finally reversing the progression of hepatic fibrosis. This article discusses the mechanism of action of IL-10 family members and their application in traditional Chinese medicine and Western medicine therapies， in order to provide new thoughts for the treatment of hepatic fibrosis.
