Research progress on impact of micro/nanoplastics exposure on reproductive health

Yan HUANG; Yuanyuan HUANG; Yanxi ZHUO; Yiqin LIN; Qipeng LI; Xiaofeng ZHENG; Wenxiang WANG; Yuchen LI; Wenya SHAO; Henggui CHEN

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Research progress on impact of micro/nanoplastics exposure on reproductive health

VernacularTitle:微纳米塑料暴露对生殖健康影响的研究进展
Author: Yan HUANG ¹ ; Yuanyuan HUANG ² ; Yanxi ZHUO ¹ ; Yiqin LIN ¹ ; Qipeng LI ¹ ; Xiaofeng ZHENG ¹ ; Wenxiang WANG ¹ ; Yuchen LI ¹ ; Wenya SHAO ¹ ; Henggui CHEN ¹
Author Information

1. .
2. Department of Public Health, Hospital of Fujian Normal University, Fuzhou, Fujian 350117, China.
Publication Type:Review
Keywords: microplastic; nanoplastic; male reproductive health; female reproductive health; toxic effect
From: Journal of Environmental and Occupational Medicine 2025;42(4):490-496
CountryChina
Language:Chinese
Abstract: Micro/nanoplastics (MNPs), recognized as emerging environmental pollutants, are widely distributed in natural environments. Due to their small particle size and significant migratory capacity, MNPs can infiltrate diverse environmental matrices, then invade and accumulate in the organism via the skin, respiration, and digestion. Recently, concerns have grown over the detrimental effects and potential toxicity of MNPs on reproductive health. This review summarized published epidemiological and toxicological studies related to MNPs exposure and their effects on reproductive health. Firstly, this review critically examined the current landscape of epidemiological evidence and found that MNPs (e.g., polystyrene, polypropylene, polyvinyl chloride, polyethylene, etc.) are present in various biological specimens from both males and females, and their presence may be associated with an increased risk of reproductive disorders. Secondly, extensive toxicological studies revealed that MNPs exposure induces reproductive health damage through mechanisms such as disrupting the microstructure of reproductive organs and altering molecular-level expressions. Oxidative stress, inflammatory responses, and apoptosis are identified as potential links between MNPs exposure and reproductive damage. Finally, this review addressed the prevalent shortcomings in existing studies and proposed future directions to tackle the challenges posed by MNPs-induced reproductive harm. These insights aim to inform strategies for safeguarding public reproductive health and ecological security, providing a scientific foundation for mitigating risks associated with MNPs pollution.