An empirical analysis on the association between sarcopenia and all-cause mortality in Chinese elderly residents
10.19428/j.cnki.sjpm.2025.24400
- VernacularTitle:中国老年居民肌少症与全因死亡率的关联实证分析
- Author:
Jie KONG
1
;
Shutie LI
1
;
Pandeng HUANG
1
;
Meihong LIU
1
;
Dongjing REN
1
Author Information
1. Department of Geriatrics, First Affiliated Hospital of Hebei North University, Zhangjiakou, Hebei 075000, China
- Publication Type:Journal Article
- Keywords:
sarcopenia;
elderly population;
all-cause mortality;
cohort study;
data of the China Health and Retirement Longitudinal Study (CHARLS)
- From:
Shanghai Journal of Preventive Medicine
2025;37(2):148-155
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo investigate the association between variant degree of sarcopenia and all-cause mortality in Chinese elderly residents, and to provide insights into the prevention and control of sarcopenia in the elderly population. MethodsData from the China Health and Retirement Longitudinal Study (CHARLS) from 2011 and 2020 were analyzed, and a total of 2 792 subjects aged 65 years or older were selected according to the inclusion and exclusion criteria. Univariate and multivariate Cox proportional hazards regression analysis were performed to explore the potential factors influencing all-cause mortality among the elderly in China, and Kaplan-Meier curves were used to visualize the survival of elderly people with variant degree of sarcopenia. Finally, a multiple-adjusted Cox proportional hazards regression model was used to control the confounding factors and explore the association between sarcopenia and all-cause mortality. ResultsBefore adjusting potential covariates, univariate and multivariate Cox proportional hazards regression models showed that 10-year all-cause mortality was significantly associated with variant degree of sarcopenia, namely possible sarcopenia (HR=1.40, 95%CI: 1.1‒1.68, P<0.001), mild-to-moderate sarcopenia (HR=1.49, 95%CI:1.20‒1.86, P<0.001), and severe sarcopenia (HR=1.68, 95%CI: 1.29‒2.19, P<0.001); after adjusting all confounders, 10-year all-cause mortality remained to be significantly associated with variant degree of sarcopenia, including probable sarcopenia (HR=1.38, 95%CI: 1.15‒1.66, P<0.001), mild-to-moderate sarcopenia (HR=1.48, 95%CI: 1.19‒1.84, P<0.001) and severe sarcopenia (HR=1.71, 95%CI: 1.31‒2.23, P<0.001). ConclusionIn Chinese elderly residents, sarcopenia is positively associated with an increased risk of 10-year all-cause mortality, and the progression of sarcopenia is positively associated with an increased risk of death.
