Effect of exosome-mediated intercellular communication on invasion and metastasis of hepatocellular carcinoma
10.13200/j.cnki.cjb.004041
- VernacularTitle:外泌体介导细胞间通讯对肝细胞癌侵袭转移的影响
- Author:
LIU Qianqian
- Publication Type:Journal Article
- From:
Chinese Journal of Biologicals
2025;38(04):502-507
- CountryChina
- Language:Chinese
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Abstract:
Hepatocellular carcinoma(HCC) is the most common primary liver malignancy with high metastasis and recurrence rates, and is one of the leading causes of cancer-related deaths worldwide. Despite improvements in detection and treatment, the prognosis for HCC remains poor. In recent years, exosomes, as a newly discovered intercellular communication mediator in the occurrence and development of tumors, deliver biologically active substances to activate or inhibit various signal transduction pathways in recipient cells, thereby regulating liver cancer cells including proliferation, invasion,metastasis, drug resistance and other malignant behaviors. However, the mechanism of exosomes on the invasion and metastasis of HCC is still unclear. Therefore, this paper systematically reviewed the regulatory mechanism of exosomes in HCC invasion and metastasis.
