Advances in anti-tumor effects of macrophage-derived exosomes
10.13200/j.cnki.cjb.004469
- VernacularTitle:巨噬细胞来源外泌体抗肿瘤作用的研究进展
- Author:
DU Wenya
- Publication Type:Journal Article
- Keywords:
Tumor;
Macrophages;
Exosomes;
miRNA
- From:
Chinese Journal of Biologicals
2025;38(04):496-501+507
- CountryChina
- Language:Chinese
-
Abstract:
Tumors are highly heterogeneous diseases, and tumor-associated macrophages(TAMs) are important immune cells in the tumor microenvironment, which are highly heterogeneous and plastic. Tumor recurrence and metastasis are an important cause of morbidity and mortality in cancer patients. Macrophage-derived exosomes(MDEs) act as messengers for cell-to-cell signaling and carry a variety of components of mother cells. A large number of studies have shown that the polarization state of macrophages plays a regulatory role in tumor progression, and MDE is closely related to tumor progression and macrophage polarization. As a new anti-tumor strategy, MDE provides new insights into tumor treatment. This paper summarizes recent research on engineered MDEs in anti-tumor and how M1 and M2 MDEs mediate tumor development, aiming to provide references for tumor treatment.
