Advances in vaccines against urinary tract infection

VernacularTitle:尿路感染疫苗的研究进展
Author: YU Cheng
Publication Type:Journal Article
Keywords: Urinary tract infection(UTI); Uropathogenic Escherichia coli(UPEC); Whole-cell/lysate vaccine; Live attenuated vaccine; Subunit vaccine
From: Chinese Journal of Biologicals 2025;38(04):481-489
CountryChina
Language:Chinese
Abstract: Urinary tract infections(UTIs) are prevalent disorders of the urinary system, primarily caused by pathogens such as uropathogenic Escherichia coli(UPEC). These infections significantly impair patients' quality of life and increase the risk of urosepsis. Although antibiotic therapy can alleviate symptoms, prolonged use often leads to drug resistance and recurrence, underscoring the necessity for developing novel prevention and treatment strategies for UTIs. In recent years, UTI vaccines, as a specific preventive approach, have shown promising progress, which are broadly categorized into three types:whole-cell/lysate vaccines, live attenuated vaccines, and subunit vaccines. Whole-cell/lysate vaccines, such as Uromune,Strovac, and OM-89/UroVaxom, have already been commercialized. In contrast, live attenuated vaccines and subunit vaccines, including ExPEC4V and ExPEC10V, remain in the preclinical research stage. In this paper, the mechanism underlying UTIs and the recent advancements in UTI vaccine development are reviewed, aiming to provide a reference for the research and development of UTI vaccines in China.