Research progress and application prospects of circular RNA
10.13200/j.cnki.cjb.004468
- VernacularTitle:环状RNA研究进展及应用前景
- Author:
HUANG Tianzhi
- Publication Type:Journal Article
- From:
Chinese Journal of Biologicals
2025;38(04):473-480+489
- CountryChina
- Language:Chinese
-
Abstract:
Circular RNA(circRNA) is a type of RNA with a circular coding structure, characterized by a circular topological structure formed during the RNA splicing process. Compared to traditional linear mRNA, circRNA exhibits enhanced stability and immunogenicity, leading to its wide-ranging potential applications in areas such as vaccines, biomarkers, and targeted therapies. This paper summarizes the research progress of circRNA, including its synthesis and degradation in vivo and in vitro, components, biological functions, and applications, aiming to provide novel insights for their utilization in vaccine design and development.
