Study on anti-constipation effect of black garlic polysaccharide
10.12206/j.issn.2097-2024.202403059
- VernacularTitle:黑蒜多糖抗便秘作用研究
- Author:
Mengyao GUAN
1
,
2
;
Tianshuang XIA
2
;
Xuhui HE
2
;
Ce SHI
2
;
Yiping JIANG
2
;
Hailiang XIN
1
,
2
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
2. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Publication Type:Originalarticles
- Keywords:
Black Garlic;
Polysaccharides;
Anti-constipation
- From:
Journal of Pharmaceutical Practice and Service
2025;43(4):190-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish the functional constipated mouse model by compound diphenoxylate, and explore the anti-constipation effect of black garlic polysaccharide. Methods Mouse small intestine ink propulsion experiment and mouse defecation experiment were carried out respectively. The mice in each experiment were randomly divided into blank group, model group, positive group and black garlic polysaccharide （0.25, 0.5, 1 g/kg） groups. Mice in blank group and model group were given distilled water, and in positive group were given lactulose oral solution. Compound diphenoxylate （5 mg/kg） was intragastric administrated after 1 week of administration, and small intestine propulsion experiment and defecation experiment were conducted respectively. Results Compared with model group, intestinal propulsion rate of black garlic polysaccharide groups was significantly increased and first dejection time was significantly shorten, and the number, weight and fecal water content increased significantly at 6 h in middle and high dose groups. Conclusion Black garlic polysaccharide could promote intestinal propelling, shorten defecation time and increase fecal water content.
