Quorum-sensing inhibition of flavonoid glycosides from Epimedium brevicornum
10.12206/j.issn.2097-2024.202409060
- VernacularTitle:淫羊藿中黄酮苷类化合物的群体感应抑制作用研究
- Author:
Xianrui JIANG
1
;
Yaqian DUAN
1
;
Chang LIU
1
;
Chengzhong ZHANG
1
Author Information
1. School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Publication Type:Originalarticles
- Keywords:
Epimedium brevicornum;
Quorum sensing;
Chromobacterium violaceum CV026;
Pseudomonas aeruginosa PAO1
- From:
Journal of Pharmaceutical Practice and Service
2025;43(4):169-173
- CountryChina
- Language:Chinese
-
Abstract:
Objective To identify flavonoid glycosides with quorum sensing inhibitory activity from Epimedium brevicornum and evaluate their bioactivity. Methods The minimum inhibitory concentrations （MICs） of five major flavonoid glycosides （baohuoside, icariin, epimedin A/B/C） and the extract of E. brevicornum were firstly determined. Subsequently, the inhibitory effects on the production of purple pigments in Chromobacterium violaceum CV026 were measured. Additionally, the biofilm formation and chitin quantification of Pseudomonas aeruginosa PAO1 were assessed. Results The extract of E. brevicornum and its primary components exhibited significant quorum sensing inhibitory activity. Particularly, icariin and epimedin C demonstrated superior inhibitory activity. Conclusion E. brevicornum demonstrates the ability to inhibit the quorum sensing system of Chromobacterium violaceum CV026 and Pseudomonas aeruginosa PAO1. Furthermore, icariin and epimedin C （100 μg/ml） show promise for development into novel drugs for quorum sensing inhibitor.
