Research progress on anti-inflammatory effect and mechanism of matrine and its derivatives
10.12206/j.issn.2097-2024.202406035
- VernacularTitle:苦参碱及衍生物的抗炎作用及其机制研究进展
- Author:
Gongjia TAO
1
;
Linlin CHEN
2
;
Zecheng SONG
2
;
Mengxiao LIU
3
,
4
;
Yan WANG
3
,
4
Author Information
1. School of Pharmacy, China Medical University, Shenyang 110122, China.
2. 2a. Department of Anesthesiology, 2b. Center for Drug Discovery and Department, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
3. 2a. Department of Anesthesiology, 2b. Center for Drug Discovery and Department, School of Pharmacy, Naval Medical University, Shanghai 200433, China
4. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
- Publication Type:Reviews
- Keywords:
Matrine;
derivatives;
anti-inflammatory action;
signal pathway
- From:
Journal of Pharmaceutical Practice and Service
2025;43(4):163-168
- CountryChina
- Language:Chinese
-
Abstract:
Matrine is an alkaloid compound isolated and extracted from the traditional Chinese medicinal plant Sophora flavescens, which has anti-tumor, anti-inflammatory, and anti-viral effects. However, its clinical application has been limited due to its low in vivo activity, short duration of efficacy, and significant toxic side effects. In response to this challenge，pharmaceutical experts modified the structure of Matrine to obtain derivatives that addressed its limitations. Currently, research on the anti-tumor effects of Matrine and its derivatives is more prevalent, while research in inflammatory-related diseases still needs further strengthening.The progress on the role and mechanism of Matrine and its derivatives in inflammatory diseases were summarized in this paper, which offered valuable insights for the development of therapeutic agents based on Matrine.
