Research progress on Sophora Flavescens of traditional Chinese medicine
10.12206/j.issn.2097-2024.202406053
- VernacularTitle:中药苦参的研究进展
- Author:
Mengxiao LIU
1
,
2
;
Linlin CHEN
3
;
Yan WANG
1
,
2
;
Junping ZHANG
1
,
2
Author Information
1. School of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China
2. Department of Anesthesiology, 2b. Center for Drug Discovery and Development, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
3. Center for Drug Discovery and Development, School of Pharmacy, Naval Medical University, Shanghai 200433, China.
- Publication Type:Reviews
- Keywords:
Sophora flavescens Ait;
matrine;
oxymatrine;
pharmacological effect;
MASM
- From:
Journal of Pharmaceutical Practice and Service
2025;43(4):156-162
- CountryChina
- Language:Chinese
-
Abstract:
Sophora Flavescens is the dried root of the leguminous plant Sophora Flavescens Ait. It was first published in Shen Nong's Herbal Classic. Sophora Flavescens contains a variety of active ingredients, mainly including matrine and oxymatrine, with anti-inflammatory, anti-tumor, anti-arrhythmia, disease-resistant pathogenic microorganisms and other pharmacological effects. Clinically, the compound preparations of Sophora Flavescens include Compound KuShen injection and KuShen gel and so on, which can be used to treat many types of cancers and improve skin, mucous pruritus, pain and other symptoms. Due to the poor bioavailability, the structure of matrine needs to be reformed. MASM, matrine derivative, only needs a low concentration to have a good therapeutic effect on sepsis and liver fibrosis. In this article, the chemical composition, pharmacological effects, compound preparations and structural modification of matrine were mainly discussed, aiming to provide a theoretical basis for the clinical application of Sophora Flavescens and the development of new drugs.
