Clinical observation of lamellar keratectomy and corneal collagen crosslinking in the treatment of superficial fungal keratitis
10.3980/j.issn.1672-5123.2025.5.20
- VernacularTitle:角膜病灶板层切除联合胶原交联术治疗浅层真菌性角膜炎的疗效观察
- Author:
Limei LIU
1
;
Xinhong HAN
1
;
Chunxiu MING
1
;
Pengfei ZHANG
1
;
Chao WANG
1
Author Information
1. Weifang Eye Hospital, Weifang 261041, Shandong Province, China
- Publication Type:Journal Article
- Keywords:
fungi;
keratitis;
keratectomy;
ultraviolet;
crosslinking agents
- From:
International Eye Science
2025;25(5):802-807
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To evaluate the clinical efficacy of lamellar keratectomy and corneal collagen crosslinking(LKCCC)in treating superficial fungal keratitis.METHODS: Retrospective analysis. Totally 79 patients(79 eyes)with superficial fungal keratitis who underwent LKCCC in our hospital from January 2014 to October 2023 were included. After admission, routine antifungal drug treatment for 7 d showed no obvious improvement or progressive aggravation. The maximum diameter of corneal lesions in all patients was ≤7 mm, the maximum depth was no more than 50% of the corneal thickness at the location, and the remaining healthy corneal thickness was ≥300 μm. The follow-up time was 90 to 112 d.RESULTS:Among the included 79 eyes, the lesions were located in the central region of the cornea in 6 eyes, in the paracentral region in 61 eyes, and in the peripheral region in 12 eyes. Hypopyon was observed in 5 cases. LKCCC was successfully administered in 79 eyes, cured in 76 eyes(96%), and failed in 3 eyes(4%). The healing time of corneal epithelium in 76 cured eyes was 3-15 d, of which 51 eyes(67%)healed within 7 d and 24 eyes(32%)healed within 3 d. The uncorrected visual acuity(UCVA)and best corrected visual acuity(BCVA)of 76 eyes of cured patients were statistically significant compared with those preoperatively(P<0.0167). Two of the 3 failed eyes were located at the edge of the lesion and recovered after re-keratectomy. One eye was located in the center of the lesion and recovered after being covered by bulbar conjunctival flap. At the last follow-up, no other complications were observed in all patients except superficial cloud and thinning of cornea.CONCLUSION:LKCCC is a rapid and effective treatment for superficial fungal keratitis and can be considered a new treatment option.
