Research progress on protein lactylation in ophthalmic diseases
10.3980/j.issn.1672-5123.2025.5.19
- VernacularTitle:蛋白质乳酸化修饰在眼科疾病中的研究进展
- Author:
Hongliang CHEN
1
;
Long SUO
1
;
Qiankun WANG
1
;
Shuang LIU
1
Author Information
1. Department of Ophthalmology, Taicang Loujiang New City Hospital, Taicang 215400, Jiangsu Province, China
- Publication Type:Journal Article
- Keywords:
lactic acid;
lactylation;
glycolysis;
post-translational modification;
ophthalmic diseases
- From:
International Eye Science
2025;25(5):797-801
- CountryChina
- Language:Chinese
-
Abstract:
Lactylation, a recently identified post-translational modification of proteins, is induced by lactic acid and can occur at multiple lysine residues in both histone and non-histone proteins. This modification plays a role in disease pathogenesis by affecting transcriptional regulation, mitochondrial metabolism, and immune inflammation. Significant advancements have been made in understanding the mechanisms of lactylation in various ophthalmic diseases, including retinal neovascularization, uveitis, melanoma, and myopia. This paper provides a comprehensive review of the relationship between lactic acid and lactylation, the regulatory mechanisms of lactylation, and the role of lactylation in different ocular diseases. Additionally, it addresses current research limitations and future directions, which is of great significance to elucidate the molecular mechanisms of lactylation in eye diseases and improving the diagnosis and targeted treatment of these conditions.
