Research progress of metabolomics in age-related macular degeneration
10.3980/j.issn.1672-5123.2025.5.12
- VernacularTitle:代谢组学在年龄相关性黄斑变性中的研究进展
- Author:
Feng WANG
1
;
Chenghong LAN
1
;
Yiling LIU
1
;
Yi SHAO
1
Author Information
1. Department of Ophthalmology, Meizhou People's Hospital, Meizhou 514000, Guangdong Province, China
- Publication Type:Journal Article
- Keywords:
age-related macular degeneration;
metabolomics;
biomarkers;
metabolic pathways
- From:
International Eye Science
2025;25(5):760-764
- CountryChina
- Language:Chinese
-
Abstract:
Age-related macular degeneration(ARMD)is a common multifactorial disease among the elderly, which may lead to irreversible vision loss; however, the pathogenesis of ARMD is still unclear. Metabolomics is a relatively new “omics” technique that can provide qualitative and quantitative information about low molecular weight metabolites that make up biological systems, thereby revealing the physiological or pathological state of cell or tissue samples at specific time points. In recent years, increasing evidence suggests that metabolic dysfunction plays an important role in the development and progression of ARMD. Metabolic pathway dysregulation involves lipid metabolism, nucleotide metabolism, amino acid metabolism, and energy metabolism, which may play important roles in the occurrence and development of ARMD. The retina is one of the most metabolically active tissues in the human body, so using metabolomics techniques to measure molecular changes in ARMD will further enhance our understanding of the pathogenesis. This will provide important insights for the prevention and treatment of ARMD, This article reviews the application of metabolomics in ARMD.
