Treatment of Neurological Diseases with Chaihu Guizhi Ganjiangtang： A Review
10.13422/j.cnki.syfjx.20250318
- VernacularTitle:柴胡桂枝干姜汤治疗神经系统疾病的研究进展
- Author:
Ge HAO
1
;
Changyu GAO
1
;
Zexin PAN
1
Author Information
1. School of Basic Medical Sciences， Heilongjiang University of Chinese Medicine， Harbin 150040， China
- Publication Type:Journal Article
- Keywords:
Chaihu Guizhi Ganjiangtang;
neurological disease;
research progress;
clinical application;
mechanism of action
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(10):313-322
- CountryChina
- Language:Chinese
-
Abstract:
Neurological diseases encompass a wide range of conditions， and their incidence and mortality rates have been increasing year by year， severely endangering the health and lives of patients. Chaihu Guizhi Ganjiangtang is a recognized prescription formulated by ZHANG Zhongjing， which has a wide application in clinical practices. It exerts the effects of harmonizing and releasing Shaoyang， warming the spleen to dispel cold， and producing fluid and astringing Yin. Clinical studies have confirmed that Chaihu Guizhi Ganjiangtang， with modified herbs or in combination with acupuncture， moxibustion， or Western medicine， exhibits remarkable efficacy， minimal adverse reactions， and high safety in the treatment of neurological diseases such as insomnia， depression， anxiety disorders， dizziness， headache， perimenopausal syndrome （PMS）， diabetic peripheral neuropathy （DPN）， post-stroke restless legs syndrome （RLS）， bipolar disorders， and tic disorders in children. Modern pharmacological studies have pointed out that the main active ingredients of single herbs in the whole formula and composition of Chaihu Guizhi Ganjiangtang， such as saikosaponins， estradiol， cinnamaldehyde， baicalin， oroxindin， gingerol， 6-shogaol， glycyrrhizic acid， and liquiritin， can exert multi-target and multi-pathway effects， including reducing oxidative stress， alleviating neuroinflammation， inhibiting ferroptosis， microglial cell activation， and neuroapoptosis， and regulating neurotransmitter levels， estrogen levels， synaptic plasticity， neuronal autophagy level， and gluconeogenic metabolism. By reviewing relevant literature in recent years， this article summarized the clinical research and mechanism of action of Chaihu Guizhi Ganjiangtang in the treatment of neurological diseases and put forward corresponding suggestions， providing references for in-depth research.
