Research progress on hepatoprotective effect and mechanism of Solanum nigrum
- VernacularTitle:龙葵的保肝作用及机制研究进展
- Author:
Yueming ZHANG
1
;
Fengwei HUANG
1
,
2
;
Jinghui ZHAI
1
;
Sixi ZHANG
1
Author Information
1. Dept. of Clinical Pharmacy，the First Hospital of Jilin University，Changchun 130021，China
2. College of Pharmaceutical Sciences，Jilin University，Changchun 130021，China
- Publication Type:Journal Article
- Keywords:
Solanum nigrum;
hepatoprotective effects;
mechanism of action;
clinical application;
liver cancer;
liver fibrosis
- From:
China Pharmacy
2025;36(7):891-896
- CountryChina
- Language:Chinese
-
Abstract:
Solanum nigrum is a traditional Chinese herb widely distributed in China. It is rich in active ingredients such as alkaloids and saponins， and has shown remarkable hepatoprotective effects and various mechanisms in the treatment of various liver diseases. It can prevent and treat chemical liver injury through anti-inflammatory， antioxidant， gut microbiota-regulating， and anti- fibrotic pathways. In the prevention and treatment of fatty liver disease， it can regulate lipid metabolism， inhibit lipogenesis， and promote fat degradation. It has potential antiviral activity against viral hepatitis. By inducing tumor cell apoptosis， arresting the cell cycle， and inhibiting tumor cell proliferation and metastasis and so on， it plays a role in the prevention and treatment of liver cancer. Clinically， S. nigrum has been used in the treatment of liver cancer and liver fibrosis after chronic hepatitis B， showing good efficacy and high safety. Future research should focus on further elucidating its mechanisms of action and promoting the development and application of new drugs， in order to benefit more patients with liver diseases.
