Research progress on drug preparations of rectal administration for ulcerative colitis
- VernacularTitle:直肠给药制剂治疗溃疡性结肠炎的研究进展
- Author:
Jun WAN
1
;
Lisha ZHOU
1
;
Tiantian LUO
1
;
Xinyue ZHANG
1
;
Shiyao CHEN
1
;
Xia ZHOU
1
Author Information
1. School of Life Science & Engineering，Southwest Jiaotong University，Chengdu 610031，China
- Publication Type:Journal Article
- Keywords:
rectal administration;
ulcerative colitis;
drug preparations;
mechanism of action;
suppository;
enema;
gel
- From:
China Pharmacy
2025;36(7):887-890
- CountryChina
- Language:Chinese
-
Abstract:
Ulcerative colitis （UC）， which is characterized by a complex and multifactorial etiology， remains one of the challenging disorders in the international field of digestive system diseases. In recent years， rectal administration preparations have made rapid progress in UC therapeutic applications. This study systematically reviews the dosage forms， mechanisms of action， and clinical applications of rectally-administered preparations for the treatment of UC. It is found that suppositories are the most commonly used dosage forms for rectal administration. The newer suppositories have the advantages of high bioavailability and good stability. Enemas can retain the drug in the intestine as much as possible to achieve the effects of diluting intestinal toxins， cleansing the bowel， and reducing inflammation. Gels can achieve a drug-sustained-release effect and effectively improve intestinal mucosal damage. The mechanism of action of this type of preparation is mainly to inhibit inflammatory cell infiltration， regulate intestinal microbial homeostasis， and increase the expression of tight-junction proteins， so as to play anti-inflammatory， regulate the intestinal bacterial flora， repair the intestinal mucosa， and other efficacies. The diversity of rectal administration forms provides a wide range of choices for the clinical treatment of UC， such as Mesalazine suppositories， Lianshao enemas， and temperature- sensitive gels loaded with drugs for UC.
