Progress in animal model studies on chronic fatigue syndrome in military seafaring operations

Shuqi CAI; Ying HE; Wenhui WU; Ruisang LIU; Yunkai ZHANG; Yong JIAO; Xiaomeng REN

Return

Progress in animal model studies on chronic fatigue syndrome in military seafaring operations

VernacularTitle:军事航海作业慢性疲劳综合征动物模型的研究进展
Author: Shuqi CAI ^{1
,

2} ; Ying HE ² ; Wenhui WU ³ ; Ruisang LIU ² ; Yunkai ZHANG ² ; Yong JIAO ² ; Xiaomeng REN ²
Author Information

1. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China
2. Naval Medical Center, Shanghai 200043, China.
3. College of Food Science and Technology, Shanghai Ocean University, Shanghai 201306, China.
Publication Type:Review
Keywords: chronic fatigue syndrome; animal model; military maritime operation; evaluation indicator; sleep disorder
From: Journal of Environmental and Occupational Medicine 2025;42(3):373-378
CountryChina
Language:Chinese
Abstract: Chronic fatigue syndrome (CFS) is a common problem in military maritime navigation, which greatly affects the safety of military missions. The use of animal models to carry out research on the mechanism of CFS and treatment measures is a common method. This paper systematically introduced the construction methods of CFS models such as single-factor and multi-factor models, summarized common evaluation indicators of CFS, including behavioral and biochemical indicators, and summed up key characteristics of CFS animal models in military oceanic navigation combined with common causes of CFS in military contexts, such as prolonged continuous work, high-intensity physical activity, sleep deprivation, psychological stress, and extreme environmental conditions. The key characteristics of the animal models included, but not limited to, chronic fatigue, sleep disorders, impaired cognitive function, psychological stress responses, and abnormal biochemical indicators. Furthermore, this article identified future research directions for CFS animal models in military oceanic navigation to enhance the application value of the models and provide robust support for the health protection and disease prevention of military personnel.