Influence of uric acid level and fasting blood glucose on the occurrence of coronary heart disease in patients with type 2 diabetes
10.3969/j.issn.1006-2483.2025.02.033
- VernacularTitle:2型糖尿病患者尿酸水平与空腹血糖等因素对冠心病发生的影响
- Author:
Yu FENG
1
;
Jianrui YANG
1
;
Jun ZHANG
1
Author Information
1. Department of Medical Laboratory , 3201 Hospital , Hanzhong , Shaanxi 723000 , China
- Publication Type:Journal Article
- Keywords:
Serum uric acid;
Fasting blood glucose;
Type 2 diabetes;
Interaction
- From:
Journal of Public Health and Preventive Medicine
2025;36(2):148-151
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the influence of blood uric acid (serum uric acid, SUA) and fasting plasma glucose (FPG） on the occurrence of coronary heart disease in patients with type 2 diabetes mellitus (T2DM). Methods T2DM patients admitted to 3201 Hospital from January 2021 to January 2024 were selected and divided into a combined coronary heart disease(CHD) and a simple diabetes mellitus (DM). The clinical data were collected, and the blood SUA and FPG levels were analyzed. The basic characteristics and biochemical indicators of the two groups were analyzed. Risk factors affecting the severity of coronary lesions were identified by multivariate logistic regression analysis. The interaction between SUA and FPG was also evaluated. Results A total of 98 T2DM patients were included in this study, including 53 and 45 patients in the DM and combined CHD groups, respectively. Compared with the DM group, low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG), SUA and FPG levels were significantly higher in the combined CHD group. The differences were all statistically significant (P<0.05). The multivariate logistic regression model analysis showed that LDL-C (OR=1.490, 95%CI: 1.044-1.824), HDL-C (OR=1.182, 95%CI: 0.846-1.314), TC (OR=1.075, 95%CI: 0.891-1.190), TG (OR=1.695, 95%CI: 1.230-2.164), SUA (OR=1.820, 95%CI: 1.294-2.424) and the FPG level (OR=2.154, 95%CI: 1.532-3.079) could be an independent risk factor for the development of CHD (OR value>1, P<0.05). The results of the interaction analysis showed a positive and additive interaction between SUA and FPG, and the difference was statistically significant (P<0.05). Conclusion Both SUA and FPG levels are independent risk factors for the occurrence of CHD. A positive additive interaction between the two may together contribute to the risk of CHD in T2DM patients.
