Effect of metformin combined with insulin detemir on intestinal flora in patients with gestational diabetes mellitus
10.3969/j.issn.1006-2483.2025.02.031
- VernacularTitle:二甲双胍联合地特胰岛素对妊娠期糖尿病患者肠道菌群的影响
- Author:
Yang ZHANG
1
,
2
;
Yuping LUO
1
,
2
;
Yuanming ZHANG
1
,
2
;
Wenjun CHENG
1
,
2
Author Information
1. Department of Obstetrics , Luzhou People'
2. s Hospital , Luzhou , Sichuan 646099 , China
- Publication Type:Journal Article
- Keywords:
Gestational diabetes mellitus;
Metformin;
Insulin detemir;
Glucose metabolism;
Intestinal flora
- From:
Journal of Public Health and Preventive Medicine
2025;36(2):139-142
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of metformin combined with insulin detemir on intestinal flora in patients with gestational diabetes mellitus (GDM). Methods A total of 176 patients with GDM admitted to Luzhou People's Hospital from May 2022 to July 2023 were selected and randomly divided into a single drug group and a combined group, with 88 cases in each group. The single drug group was treated with insulin detemir, and the combined group was given metformin combined with insulin detemir. The glucose metabolism levels and intestinal flora distribution were compared between the two groups before treatment and during delivery. The maternal-infant outcomes were statistically analyzed and compared between the two groups. Results During delivery, the levels of fasting plasma glucose (FPG), glycosylated hemoglobin (HbAlc), and largest amplitude of glycemic excursions (LAGE), and the contents of Enterobacterium, Enterococcus and Escherichia coli in both groups were reduced compared with those before treatment, and the above indicators in the combined group were lower than those in the single drug group (all P<0.05). The contents of Bifidobacterium and Lactobacillus were increased in both groups, and the indicators were higher in the combined group than those in the single drug group (all P<0.05). There was no significant difference in adverse maternal-infant outcomes between the two groups (P>0.05). Conclusion Metformin combined with insulin detemir can effectively reduce blood glucose levels and improve intestinal flora distribution in patients with GDM, without increasing adverse maternal-infant outcomes.
