Correlation between insulin resistance, serum uric acid and blood lipids levels and renal damage in patients with type 2 diabetes mellitus
10.3969/j.issn.1006-2483.2025.02.030
- VernacularTitle:2型糖尿病患者胰岛素抵抗血尿酸及血脂水平与肾脏损害的相关性
- Author:
Lu ZHANG
1
;
Nana LI
1
Author Information
1. Department of Nephrology and Rheumatology , Shandong Provincial Third Hospital , Jinan , Shandong 250031, China
- Publication Type:Journal Article
- Keywords:
Type 2 diabetes mellitus;
Insulin resistance;
Serum uric acid;
Blood lipids;
Renal damage
- From:
Journal of Public Health and Preventive Medicine
2025;36(2):135-138
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the correlation between insulin resistance, serum uric acid (SUA) and blood lipids levels and diabetic kidney disease (DKD) with renal damage in patients with type 2 diabetes mellitus (T2DM). Methods A retrospective analysis was conducted on the clinical case data of 320 T2DM patients admitted to the hospital from January 2021 to December 2023. According to the urinary albumin/creatinine ratio (UACR), the above patients were divided into T2DM group (UACR<30 mg/g, 136 cases), mild DKD group (UACR of 30 mg/g-300 mg/g, 106 cases) and moderate-to-severe DKD group (UACR>300 mg/g, 78 cases). The clinical baseline data, insulin resistance index (HOMA-IR), SUA, and blood lipids (total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C)) were collected and compared among the three groups. Spearman analysis was performed to analyze the correlation between HOMA-IR, SUA, blood lipids and occurrence of renal damage. Results Compared with the T2DM group, the levels of UACR, HOMA-IR, SUA, TC and TG in the mild DKD group and the moderate-to-severe DKD group were higher, and the levels the above indicators in the moderate-to-severe DKD group were higher than those in the mild DKD group (P<0.05). Spearman correlation test results indicated that HOMA-IR, SUA, TC and TG were positively correlated with renal damage in patients with T2DM (r=0.486, 0.537, 459, 0.472, P<0.05). Conclusion The changes of insulin resistance, SUA and blood lipids are closely related to the occurrence and development of DKD in patients with T2DM, which can be used to evaluate their renal damage and grading.
