Epidemiological investigation and post-natal follow-up analysis of hepatitis B exposed children in Wenzhou area
10.3969/j.issn.1006-2483.2025.02.029
- VernacularTitle:温州地区乙肝暴露儿童流行病学调查及随访分析
- Author:
Lulu PAN
1
;
Jianle SUN
1
;
Qian XU
1
;
Enshu WANG
1
Author Information
1. Department of Children Health , Women and Children Health Guidance Center of Wenzhou , Wenzhou , Zhejiang 325000 , China
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Mother-to-infant transmission;
Epidemiology;
Blocking;
Follow-up
- From:
Journal of Public Health and Preventive Medicine
2025;36(2):131-134
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the situation of hepatitis B immune blocking and the growth and development of hepatitis B exposed children within one year after birth, and to provide evidence for formulating and optimizing measures for maternal and infant blocking in Wenzhou. Methods The hepatitis B infection status during pregnancy and birth was collected, hepatitis B immunoglobulin and vaccine were analyzed, and a follow-up on the immune blocking effect, growth and development, and the nutritional status of children exposed to hepatitis B was conducted. Statistical analysis of data was carried out through SPSS 26.0. Results In 2021, 6.07% of newborns in Wenzhou were exposed to hepatitis B, of which 28.37% were highly exposed children. The prevalence rates for males and females were 6.42% and 5.70%, respectively, and the difference was statistically significant (χ2=13.744, P<0.001). The prevalence rates in mountainous and non-mountainous counties were 6.35% and 5.94%, respectively, and the difference was statistically significant (χ2=5.72, P < 0.001). In 2021, the mother-to-child transmission rate of children exposed to hepatitis B was 0.54‰. There were no significant differences in the height, weight, hemoglobin and neuropsychological development of hepatitis B exposed children compared with non-exposed children (P < 0.001). Conclusion The number of children exposed to hepatitis B in mountainous counties is significantly higher than that in non-mountainous counties in Wenzhou, and the number of men is significantly higher than that of women. The proportion of highly exposed children is relatively high. The effect of mother-to-child blocking is good, and there is no significant difference between the growth and development of children exposed to hepatitis B and no-exposed children during follow-up.
