Epidemic characteristics and viral genotypes of acute viral hepatitis B in Tianjin in 2018 - 2022
10.3969/j.issn.1006-2483.2025.02.004
- VernacularTitle:2018—2022年天津市急性乙型病毒性肝炎流行特征及病毒基因型分析
- Author:
Guoping ZHANG
1
;
Yongxin WANG
1
;
Haiyan HE
1
;
Yong LIU
1
;
Weishen WU
1
Author Information
1. Tianjin Centers for Disease Control and Prevention , Tianjin 300011 , China
- Publication Type:Journal Article
- Keywords:
Hepatitis B;
Acute;
Epidemiological characteristics;
Genotype
- From:
Journal of Public Health and Preventive Medicine
2025;36(2):17-21
- CountryChina
- Language:Chinese
-
Abstract:
Objective To understand the epidemic characteristics and genotype distribution of acute hepatitis B in Tianjin, and to find out the relationship between genotype and epidemic characteristics. Methods The information of acute hepatitis B cases with a local address in Tianjin was collected through the National Infectious Disease Surveillance System in Tianjin from 2018 to 2022. The patient outcomes were followed up through hospital system records and telephone survey, and hepatitis B virus (HBV) genotypes were detected by fluorescent PCR. Results From 2018 to 2022, there were 387 cases of acute hepatitis B with local address reported in Tianjin, with an average annual reported incidence rate of 0.52/100 000, showing a downward trend in general (χ2=28.553，P<0.001). The reported male to female incidence ratio was 1.68. The age distribution was mainly concentrated in the 30-65 age group, with the highest incidence rate (1.22/100 000) reported in the 35-39 age group. 72.87% of cases showed negative HBsAg after 6 months of follow-up following diagnosis. The proportion of cadres and staff who turned negative (92.16%) was significantly higher than that of those who did not turn negative (0%). The median ALT (1508.00 U/L) in the turning negative group was significantly higher than that in the non-turning negative group (976.00 U/L). Among 315 cases with successful genotyping, genotype C accounted for 81.27%, and genotype B accounted for 14.92%, with 47 cases. The median ALT of genotype B patients with acute hepatitis B (1585.00 U/L) was significantly higher than that of genotype C patients (988.00 U/L). Conclusion The reported incidence rate of acute hepatitis B in Tianjin is relatively low, and shows a downward trend. Young and middle-aged men are prone to infect HBV. Genotype C is the main genotype, and genotype B HBV causes more serious liver damage in patients with acute hepatitis B.
