Trend in pertussis disease burden in China based on the Global Burden of Disease data in 1990 - 2021
10.3969/j.issn.1006-2483.2025.02.003
- VernacularTitle:1990—2021年基于GBD数据分析中国百日咳疾病负担变化趋势
- Author:
Chengwei HUANG
1
,
2
;
Xueqiong LAO
1
;
Xianan LIANG
1
;
Zhifeng ZHOU
3
;
Lin CAI
3
;
Haibing CHEN
1
,
4
Author Information
1. Nanning Center for Disease Control and Prevention , Nanning , Guangxi 530023 , China
2. Shenzhen Field Epidemiology Training Program , Shenzhen , Guangdong 518055 , China
3. Futian District Center for Disease Control and Prevention , Shenzhen , Guangdong 518028 , China
4. Nanning Field Epidemiology Training Program , Nanning , Guangxi 530023 , China
- Publication Type:Journal Article
- Keywords:
China;
Pertussis;
Disease burden;
Trend analysis
- From:
Journal of Public Health and Preventive Medicine
2025;36(2):12-16
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the trends in the disease burden of pertussis in China from 1990 to 2021, and to provide a basis for the development of effective prevention and control strategies. Methods Using the 2021 Global Burden of Disease Study (GBD) database, the incidence, mortality, and disability-adjusted life years (DALYs), as well as the age-standardized rates of pertussis in China from 1990 to 2021 were analyzed. Descriptive statistical methods were employed to analyze the characteristics of the pertussis disease burden, and the Joinpoint regression model was used to analyze the trends in pertussis disease burden. Results From 1990 to 2021, the incidence, mortality, and DALYs of pertussis in China decreased from 1 503 800 cases, 10 951 deaths, and 954 900 person-years to 65 400 cases, 548 deaths, and 46 500 person-years, representing a decrease of 95.65%, 95.00%, and 95.13%, respectively. The corresponding age-standardized rates also decreased by 93.58%, 92.47%, and 92.53%, respectively. The Joinpoint regression model revealed a significant downward trend in the age-standardized incidence, mortality, and DALYs rates for pertussis (AAPCs were -8.32%, -9.65%, and -9.58%, respectively, P<0.001). The disease burden was slightly higher in females than in males, with the majority of cases occurring in children under 10 years old, particularly in infants under 1 year old, where the burden was the heaviest. As age increased, the disease burden decreased. Conclusion Between 1990 and 2021, the overall disease burden of pertussis in China showed a significant downward trend, with gender and age differences. Special attention should be given on the prevention and control of pertussis in children under 10 years old, especially in infants under 1 year old.
