Progress of Anti-osteoporosis Research of Traditional Chinese Medicine Based on Zebrafish Model
10.13422/j.cnki.syfjx.20241816
- VernacularTitle:基于斑马鱼模型的中药抗骨质疏松的评价方法与疗效研究进展
- Author:
Henghong WANG
1
;
Xinyu FAN
1
;
Yihan GAO
1
;
Zhilue LUO
1
;
Peng DUAN
2
;
Yunfeng ZHOU
1
Author Information
1. Xiangyang No.1 People′s Hospital， Hubei Universi ty of Medicine， Xiangyang 441000，China
2. Key Laboratory of Zebrafish Modeling and Drug Screening for Human Diseases of Xiangyang City， Xiangyang No.1 People's Hospital， Hubei University of Medicine， Xiangyang 441000，China
- Publication Type:Journal Article
- Keywords:
osteoporosis;
zebrafish;
traditional Chinese medicine;
signalling pathway;
drug screening
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2025;31(9):323-330
- CountryChina
- Language:Chinese
-
Abstract:
Osteoporosis （OP） is a systemic metabolic disease with a strong correlation with age. The prevalence of osteoporosis is rising annually as a consequence of the growing issue of population ageing. The current treatments for OP have numerous shortcomings. In contrast， traditional Chinese medicine has a long history and a rich species diversity. Furthermore， recent years have seen an increase in the number of studies examining the anti-OP properties of traditional Chinese medicine. This may provide a safe and effective alternative strategy for the treatment of OP. The zebrafish， due to its favourable optical transparency and high homology with human genes， has been extensively employed as an animal research model in the investigation of human skeletal-related disease mechanisms and drug screening. This paper presents a review of anti-osteoporosis studies of traditional Chinese medicine using zebrafish as a model for osteoporosis. It also provides a summary of the experimental evaluation methods involved in such studies， an analysis of the current status of traditional Chinese medicine in the treatment of osteoporosis using zebrafish as a model， and a summary of the mechanism of action and the signalling pathways involved in traditional Chinese medicine in the anti-osteoporosis treatment of zebrafish. The current research status of Chinese medicine in the treatment of OP was analysed， as well as the mechanism of action of Chinese medicine against OP and the signalling pathways involved. Furthermore， the advantages and disadvantages of various zebrafish modelling methods of OP were compared with those of traditional animal models. The objective of this study is to provide a reference for the evaluation method of the zebrafish model in the study of bone-related diseases， as well as for the study of the mechanism of action of traditional Chinese medicine against OP and for the reference of the research and development of new drugs.
